RT Journal Article
T1 Accessing molecular complexity from methane and other GaseousAlkanes via photocatalytic cascade cyclization
A1 Nair, Akshay M.
A1 Malga Díaz, José Manuel
A1 Martínez Acevedo, Nicolás
A1 Fañanás-Mastral, Martín
AB The direct transformation of simple and abun-dant feedstocks into structurally complex moleculesremains a central challenge in modern organic synthesis.Herein, we report a method for the oxidative cascadecyclization of N-aryl and N-benzoyl acrylamide deriva-tives, promoted by methane and other gaseous alkanes.This transformation is enabled by a readily available ironcatalyst in combination with N-fluorobenzenesulfonimide(NFSI) as the oxidant, proceeding under mild conditionsto afford a diverse array of N-heterocyclic frameworks inhigh yields. Late-stage functionalization studies highlightthe utility of methane in the synthesis of biologicallyrelevant scaffolds. Moreover, the Fe/NFSI system facili-tates a radical sampling regime that enables the selectivefunctionalization of less reactive primary C─H bonds.Overall, this work establishes a sustainable and versatileplatform for constructing molecular complexity directlyfrom gaseous alkanes.
PB Wiley
PB Gesellschaft Deutscher Chemiker
SN 1433-7851
YR 2026
FD 2026-01-28
LK https://hdl.handle.net/10347/46799
UL https://hdl.handle.net/10347/46799
LA eng
NO Nair, A. M., Malga, J. M., Martínez‐Acevedo, N., & Fañanás‐Mastral, M. (2026). Accessing Molecular Complexity from Methane and Other Gaseous Alkanes via Photocatalytic Cascade Cyclization. Angewandte Chemie International Edition, 65(5), e25713. https://doi.org/10.1002/anie.202525713
NO Financial support from the European Research Council (ERC-CoG 863914-BECAME), the Agencia Estatal de Investigación (PID2023-151875NB-I00), the Xunta de Galicia (ED431C 2022/27); Centro de investigación do Sistema universitario de Galicia accreditation 2023–2027, (ED431G 2023/03) and the European Regional Development Fund (ERDF) is gratefully acknowledged. A.M.N. thanks the European Union’s Horizon Europe research and innovation program for a Marie Skłodowska-Curie postdoctoral fellowship (MePhoCat, No.101150274). J.M.M. thanks Xunta de Galicia for a predoctoral fellowship (ED481A-2024–112).
DS Minerva
RD 22 may 2026