RT Journal Article
T1 Optimization of Drug Permeation from 8% Ciclopirox Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers
A1 Cutrín Gómez, Elena
A1 Conde Penedo, Andrea
A1 Anguiano Igea, Soledad
A1 Gómez Amoza, José Luis
A1 Otero Espinar, Francisco Javier
K1 Transungual drug delivery
K1 Nail
K1 Medicated nail lacquers
K1 Onychomycosis
K1 Polypseudorotaxanes
K1 Methyl-β-cyclodextrin
K1 Poloxamers
K1 Ciclopirox olamine
K1 Ciclopirox base
AB Cyclodextrin/poloxamer-soluble polypseudorotaxane-based nail lacquers have demonstrated significant capacity for promoting the permeation of drugs into the nail plate. Furthermore, previous studies have shown that the use of hydroalcoholic blends as vehicles promotes drug permeation. The work described herein studies the effect of the type of alcohol used in the lacquer preparation, and the composition of the vehicle is optimized to obtain soluble doses of 8% and to promote the diffusion of ciclopirox base and olamine across the nail. Permeation studies on different types of alcohols show that optimum results are achieved with short-chain alcohols, and that results become less satisfactory the higher the number of alcohol carbons. In addition, solubility and penetration studies on the bovine hoof have enabled the composition of the lacquer to be optimized for both forms of ciclopirox. The results suggest that optimized lacquers have better ciclopirox diffusion and penetration properties than the commercial reference lacquer. Lastly, in vivo studies in which optimized ciclopirox olamine lacquer was applied for 45 days to the nails of healthy volunteers showed that it caused no negative effects or changes to the nail surface. These results demonstrate the significant potential of cyclodextrin/poloxamer-soluble polypseudorotaxane-based nail lacquers for the ungual administration of drugs
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23780
UL http://hdl.handle.net/10347/23780
LA eng
NO Cutrín-Gómez, E.; Conde-Penedo, A.; Anguiano-Igea, S.; Gómez-Amoza, J.L.; Otero-Espinar, F.J. Optimization of Drug Permeation from 8% Ciclopirox Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers. Pharmaceutics 2020, 12, 231
NO This research was funded by Xunta de Galicia grant number GRC2013/015 and GPC2017/015
DS Minerva
RD 24 abr 2026