RT Journal Article
T1 Inferring the Demographic History of African Farmers and Pygmy Hunter–Gatherers Using a Multilocus Resequencing Data Set
A1 Patin, Etienne
A1 Laval, Guillaume
A1 Barreiro, Luis B.
A1 Salas Ellacuriaga, Antonio
A1 Semino, Ornella
A1 Santachiara-Benerecetti, Silvana
A1 Kidd, Kenneth K.
A1 Kidd, Judith R.
A1 der Veen, Lolke Van
A1 Hombert, Jean-Marie
A1 Gessain, Antoine
A1 Froment, Alain
A1 Bahuchet, Serge
A1 Heyer, Evelyne
A1 Quintana-Murci, Lluís
AB The transition from hunting and gathering to farming involved a major cultural innovation that has spread rapidly overmost of the globe in the last ten millennia. In sub-Saharan Africa, hunter–gatherers have begun to shift toward anagriculture-based lifestyle over the last 5,000 years. Only a few populations still base their mode of subsistence on huntingand gathering. The Pygmies are considered to be the largest group of mobile hunter–gatherers of Africa. They dwell inequatorial rainforests and are characterized by their short mean stature. However, little is known about the chronology ofthe demographic events—size changes, population splits, and gene flow—ultimately giving rise to contemporary Pygmy(Western and Eastern) groups and neighboring agricultural populations. We studied the branching history of Pygmyhunter–gatherers and agricultural populations from Africa and estimated separation times and gene flow between thesepopulations. We resequenced 24 independent noncoding regions across the genome, corresponding to a total of ,33 kbper individual, in 236 samples from seven Pygmy and five agricultural populations dispersed over the African continent. Weused simulation-based inference to identify the historical model best fitting our data. The model identified included theearly divergence of the ancestors of Pygmy hunter–gatherers and farming populations ,60,000 years ago, followed by asplit of the Pygmies’ ancestors into the Western and Eastern Pygmy groups ,20,000 years ago. Our findings increaseknowledge of the history of the peopling of the African continent in a region lacking archaeological data. An appreciation ofthe demographic and adaptive history of African populations with different modes of subsistence should improve ourunderstanding of the influence of human lifestyles on genome diversity.
PB Plos
SN 1553-7390
YR 2009
FD 2009
LK http://hdl.handle.net/10347/22771
UL http://hdl.handle.net/10347/22771
LA eng
NO Patin E., Laval G., Barreiro L.B., Salas A., Semino O., et al. (2009). Inferring the Demographic History of African Farmers and Pygmy Hunter–Gatherers Using a Multilocus Resequencing Data Set. PLoS Genet 5(4): e1000448
NO Financial support was provided by the Institut Pasteur, the Centre National de la Recherche Scientifique (CNRS), an Agence Nationale de la Recherche (ANR) research grant (ANR-05-JCJC-0124-01 to LQM), and an Action Concertée Incitative grant (ACI - E. HEYER 9ADO0590/1B1ENV 5F5302 to EH). KKK and JRK are supported by USPHS grant P01 GM057672. EP is supported by the Fondation pour la Recherche Médicale (FRM)
DS Minerva
RD 28 abr 2026