RT Journal Article
T1 Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus
A1 Heredia, Margarita
A1 Rodríguez, Natalia
A1 Sánchez Robledo, Virginia
A1 Criado, José María
A1 Fuente, Antonio de la
A1 Devesa Múgica, Jesús
A1 Devesa Peleteiro, Pablo
A1 Sánchez Riolobos, Adelaida
K1 Growth hormone
K1 Traumatic brain injury
K1 Neural plasticity
K1 Neurogenesis
K1 Actin
K1 Nestin
K1 Striatum
K1 Thalamus
AB Previously we demonstrated, in rats, that treatment with growth hormone (GH) and rehabilitation, carried out immediately after a motor cortical ablation, significantly improved the motor affectation produced by the lesion and induced the re-expression of nestin in the contralateral motor cortex. Here we analyze cortical proliferation after ablation of the frontal motor cortex and investigate the re-expression of nestin in the contralateral motor cortex and the role of the striatum and thalamus in motor recovery. The rats were subjected to ablation of the frontal motor cortex in the dominant hemisphere or sham-operated and immediately treated with GH or the vehicle (V), for five days. At 1 dpi (days post-injury), all rats received daily injections (for four days) of bromodeoxyuridine and five rats were sacrificed at 5 dpi. The other 15 rats (n = 5/group) underwent rehabilitation and were sacrificed at 25 dpi. GH induced the greatest number of proliferating cells in the perilesional cortex. GH and rehabilitation produced the functional recovery of the motor lesion and increased the expression of nestin in the striatum. In the thalamic ventral nucleus ipsilateral to the lesion, cells positive for nestin and actin were detected, but this was independent on GH. Our data suggest that GH-induced striatal nestin is involved in motor recovery
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/23836
UL http://hdl.handle.net/10347/23836
LA eng
NO Heredia, M.; Rodríguez, N.; Sánchez Robledo, V.; Criado, J.M.; de la Fuente, A.; Devesa, J.; Devesa, P.; Sánchez Riolobos, A. Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus. Int. J. Mol. Sci. 2019, 20, 5770
NO This research was funded by Foundation Foltra (Teo, Spain), grant number 2018-8
DS Minerva
RD 27 abr 2026