RT Journal Article
T1 Simple thermal treatment to improve the MRI and magnetic hyperthermia performance of hybrid iron Oxide-Mesoporous silica nanocarriers
A1 García Acevedo, Pelayo
A1 Vargas Osorio, Zulema
A1 Velasco Rodríguez, Brenda
A1 González Gómez, Manuel Antonio
A1 Arnosa Prieto, Ángela
A1 Alves, Lisandra Cristina de Castro
A1 Iglesias Rey, Ramón
A1 Taboada Antelo, Pablo
A1 Piñeiro Redondo, Yolanda
A1 Rivas Rey, José
K1 Magnetic nanocomposites
K1 Magnetic hyperthermia
K1 Magnetic resonance imaging
K1 Mesoporous silica
K1 Drug delivery systems
AB The design of multifunctional nanocomposites (NCs), incorporating a variety of controllable properties from nanostructured materials, spans their applicability as nanotools in biomedical applications. Santa Barbara Amorphous (SBA-15) mesoporous silica has showcased remarkable capabilities, ranging from bone regeneration to drug delivery. Its synergy with magnetic nanoparticles (MNPs) further broadens its scope as a theranostic agent, seamlessly integrating both therapeutic and diagnostic functions. However, efficiency issues arise due to MNP anchoring, necessitating novel solutions for optimization. This study focuses on enhancing the magnetic properties of hybrid iron oxide-SBA-15 mesoporous silica NCs through a simplified thermal procedure. The aim is to optimize their magnetic performance for dual functionality as contrast agents for magnetic resonance imaging (MRI) and as effective heaters in magnetic hyperthermia (MH) processes, while preserving the cylindrical mesoporous structure, high surface area, and high loading capacity compared to conventional ceramics. The investigation highlights that the impact of heat treatment on physicochemical properties varies depending on the compositions of the NCs. Specifically, the transversal relaxivity in MRI was doubled, accompanied by an enhanced Néel contribution in MH. This enhancement was achieved while maintaining the same biocompatibility as non-treated NCs, as demonstrated in evaluations with two cancer cell lines (HeLa and T-731 astrocytes), revealing low toxicity at concentrations up to 200 μg/mL
PB Elsevier
SN 0167-7322
YR 2024
FD 2024
LK http://hdl.handle.net/10347/33846
UL http://hdl.handle.net/10347/33846
LA eng
NO Journal of Molecular Liquids, Volume 398, 2024, 124299
NO This work was supported by the European Commission under the BOW project (FETPROACT-EIC-05-2019, Grant 952183), CARTsol project (PLEC2022-009217 funded by MICINN/AEI /10.13039/501100011033 and NextGenerationEU/ PRTR) and partially supported by the Spanish Ministry of Science and Innovation (ref PID2020-112626RB-C21), Modalities «Research Challenges» and «Knowledge Generation» and the Regional Consellería de Innovación Program for the Grupos de Referencia Competitiva 2021 —GRC2021 project of Xunta de Galicia. Zulema Vargas gratefully acknowledges the financial support from the European Uniońs Horizon 2020 Research and Innovation Programme under grant agreement No 739566. R. Iglesias-Rey (CP22/00061) from the Miguel Servet Program of Instituto de Salud Carlos III and Co-financed by the EU. P.T. also thanks Agencia Estatal de Investigación (AEI) by project PID2019-109517RB-I00) and from Xunta de Galicia, project ED431C2022/18. European Regional Development Funds are also acknowledged
DS Minerva
RD 26 abr 2026