RT Journal Article
T1 The role of size polydispersity in magnetic fluid hyperthermia: average vs. local infra/over-heating effects
A1 Munoz-Menendez, Cristina
A1 Conde Leborán, Iván
A1 Baldomir Fernández, Daniel
A1 Chubykalo-Fesenko, Oksana
A1 Serantes Abalo, David
K1 Magnetic hyperthermia
K1 Magnetic nanoparticles
K1 Local heating
AB An efficient and safe hyperthermia cancer treatment requires the accurate control of the heating performance of magnetic nanoparticles, which is directly related to their size. However, in any particle system the existence of some size polydispersity is experimentally unavoidable, which results in a different local heating output and consequently a different hyperthermia performance depending on the size of each particle. With the aim to shed some light on this significant issue, we have used a Monte Carlo technique to study the role of size polydispersity in heat dissipation at both the local (single particle) and global (macroscopic average) levels. We have systematically varied size polydispersity, temperature and interparticle dipolar interaction conditions, and evaluated local heating as a function of these parameters. Our results provide a simple guide on how to choose, for a given polydispersity degree, the more adequate average particle size so that the local variation in the released heat is kept within some limits that correspond to safety boundaries for the average-system hyperthermia performance. All together we believe that our results may help in the design of more effective magnetic hyperthermia applications
PB Royal Society of Chemistry
SN 1463-9076
YR 2015
FD 2015-09-23
LK http://hdl.handle.net/10347/16792
UL http://hdl.handle.net/10347/16792
LA eng
NO Munoz-Menendez, C., Conde-Leboran, I., Baldomir, D., Chubykalo-Fesenko, O., & Serantes, D. (2015). The role of size polydispersity in magnetic fluid hyperthermia: average vs. local infra/over-heating effects. Physical Chemistry Chemical Physics, 17(41), 27812-27820. doi: 10.1039/c5cp04539h
NO This is the accepted manuscript of the following article: Munoz-Menendez, C., Conde-Leboran, I., Baldomir, D., Chubykalo-Fesenko, O., & Serantes, D. (2015). The role of size polydispersity in magnetic fluid hyperthermia: average vs. local infra/over-heating effects. Physical Chemistry Chemical Physics, 17(41), 27812-27820. doi: 10.1039/c5cp04539h
NO The authors thank the Centro de Supercomputación de Galicia (CESGA) for the computational facilities. This work was co-financed by the EU (project FEMTOSPIN, Ref. NNP3-SL-2012-281043), the Spanish MEC (FIS2010-20979C02-02 and MAT2009-08165) and Xunta de Galicia (INCITE 08PXIB236052PR). D.S. acknowledges Xunta de Galicia (Spain) for financial support under the Plan I2C. The FPI Spanish program supported I. C-L.
DS Minerva
RD 24 abr 2026