RT Dissertation/Thesis
T1 Photobacterium damselae subsp. damselae: analysis of the genetic diversity and characterization of a conserved two-component system regulating virulence
A1 Terceti, Mateus de Souza
K1 Photobacterium damselae subsp. damselae
K1 two-component system regulating
K1 diversity
AB Photobacterium damselae subsp. damselae is an emerging pathogen of marine aquaculture. By combining phenotypic and genotypic data, and comparative genomics analyses, we here show that this pathogen exhibits a high genetic diversity and that outbreaks in fish are caused by multiclonal populations. We identified and characterized the RstAB two-component signal transduction system, a major positive regulator of virulence and of many aspects of cell physiology in this bacterium. The RstAB regulon comprises the major cytotoxins Dly, PhlyP and PhlyC, as well as hitherto unreported proteins secreted by the type two secretion system (T2SS), that may constitute novel virulence factors in this pathogen.
YR 2018
FD 2018
LK http://hdl.handle.net/10347/18131
UL http://hdl.handle.net/10347/18131
LA eng
DS Minerva
RD 23 abr 2026