RT Dissertation/Thesis
T1 Neuroprotective effects of potent antioxidant molecules isolated from Bifurcaria bifurcata and Codium tomentosum in a in vitro and in vivo Parkinson Disease model
A1 Silva, Joana Rita Martins da
K1 Parkinson's disease
K1 SH-SY5Y cells
K1 Neuroprotection
K1 Marine natural products
K1 Oxidative stress
K1 Mitochondrial dysfunction
K1 Apoptosis
K1 Anti-inflammatory activity
AB The main objective of this thesis was to study the chemical profile of thealgae Bifurcaria bifurcata and Codium tomentosum collected on the coast of Peniche (Portugal), evaluating theantioxidant, neuroprotective and anti-inflammatory activities of its main metabolites in an in vitro model ofParkinson's disease induced by the neurotoxin 6-hydroxydopamine on SH-SY5Y cells. This study allowed toidentify 6 compounds, in which only 2 (eleganolone and loliolide) demonstrated to have neuroprotective and antiinflammatorypotential. The results obtained in this work consisted of an initial approach in relation to theneuroprotective potential in a model of Parkinson's disease, allowing these compounds can studied in morecomplex models and to be used as pharmacological agents in the treatment of Parkinson's disease.
YR 2021
FD 2021
LK http://hdl.handle.net/10347/27247
UL http://hdl.handle.net/10347/27247
LA eng
DS Minerva
RD 22 abr 2026