RT Journal Article
T1 Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy
A1 Triana Martínez, Francisco
A1 Loza García, María Isabel
A1 Domínguez Medina, Eduardo
K1 Cellular senescence
K1 Quiescence
K1 Senolytic
K1 Stemness
AB Here, we provide an overview of the importance of cellular fate in cancer as a group of diseases of abnormal cell growth. Tumor development and progression is a highly dynamic process, with several phases of evolution. The existing evidence about the origin and consequences of cancer cell fate specification (e.g., proliferation, senescence, stemness, dormancy, quiescence, and cell cycle re-entry) in the context of tumor formation and metastasis is discussed. The interplay between these dynamic tumor cell phenotypes, the microenvironment, and the immune system is also reviewed in relation to cancer. We focus on the role of senescence during cancer progression, with a special emphasis on its relationship with stemness and dormancy. Selective interventions on senescence and dormancy cell fates, including the specific targeting of cancer cell populations to prevent detrimental effects in aging and disease, are also reviewed. A new conceptual framework about the impact of synthetic lethal strategies by using senogenics and then senolytics is given, with the promise of future directions on innovative anticancer therapies.
PB MDPI
YR 2020
FD 2020-02-03
LK https://hdl.handle.net/10347/45389
UL https://hdl.handle.net/10347/45389
LA eng
NO Triana-Martínez, F., Loza, M. I., & Domínguez, E. (2020). Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy. Cells, 9(2), 346. https://doi.org/10.3390/cells9020346
DS Minerva
RD 29 abr 2026