RT Dissertation/Thesis
T1 Improving Osteoarthritis Therapy through the design of Intra-articular Drug Delivery Systems engineered with Artificial Intelligence Tools
A1 Martínez Borrajo, Rebeca
K1 nanoparticles
K1 microspheres
K1 DMOADs
K1 Osteoarthritis
AB This thesis highlights the crucial role of Artificial Intelligence (AI) tools indesigning, developing, and optimizing novel formulations with potential asdisease modifying osteoarthritis drugs (DMOADs). In this regard, AI toolsenabled the establishment of robust protocols to prepare nanoparticles andmicrospheres of specific desired characteristics. The drug delivery systemsdeveloped in this thesis demonstrated its potential as DMOADs by targeting thetwo main hallmarks of OA: inflammation and cartilage degradation. Thisapproach is achieved by following three independent but closely related strategies;inflammation control, macrophage phenotype modulation and reversing diseaseprogression by modulating chondrocyte senescence. The use of AI tools waspivotal in achieving these advancements, offering innovative methodologies thatsurpassed traditional approaches in drug delivery systems design.
YR 2024
FD 2024
LK http://hdl.handle.net/10347/34986
UL http://hdl.handle.net/10347/34986
LA eng
DS Minerva
RD 24 abr 2026