RT Journal Article
T1 Modular Synthesis of PEG-Dendritic Block Copolymers by Thermal Azide–Alkyne Cycloaddition with Internal Alkynes and Evaluation of their Self-Assembly for Drug Delivery Applications
A1 Parcero Bouzas, Samuel
A1 Correa Chinea, Juan Francisco
A1 Jiménez López, Celia
A1 Delgado González, Bruno
A1 Fernández Megía, Eduardo
K1 Azides
K1 Copolymers
K1 Dendrons
K1 Dynamic Light Scattering
K1 Micelles
AB Linear–dendritic block copolymers assemble in solution due to differences in the solubility or charge properties of the blocks. The monodispersity and multivalency of the dendritic block provide unparalleled control for the design of drug delivery systems when incorporating poly(ethylene glycol) (PEG) as a linear block. An accelerated synthesis of PEG-dendritic block copolymers based on the click and green chemistry pillars is described. The tandem composed of the thermal azide–alkyne cycloaddition with internal alkynes and azide substitution is revealed as a flexible, reliable, atom-economical, and user-friendly strategy for the synthesis and functionalization of biodegradable (polyester) PEG-dendritic block copolymers. The high orthogonality of the sequence has been exploited for the preparation of heterolayered copolymers with terminal alkenes and alkynes, which are amenable for subsequent functionalization by thiol–ene and thiol–yne click reactions. Copolymers with tunable solubility and charge were so obtained for the preparation of various types of nanoassemblies with promising applications in drug delivery.
PB American Chemical Society
YR 2024
FD 2024
LK http://hdl.handle.net/10347/34625
UL http://hdl.handle.net/10347/34625
LA eng
NO Samuel Parcero-Bouzas, Juan Correa, Celia Jimenez-Lopez, Bruno Delgado Gonzalez, and Eduardo Fernandez-Megia. Modular Synthesis of PEG-Dendritic Block Copolymers by Thermal Azide–Alkyne Cycloaddition with Internal Alkynes and Evaluation of their Self-Assembly for Drug Delivery Applications. Biomacromolecules 2024 25 (5), 2780-2791 DOI: 10.1021/acs.biomac.3c01429
DS Minerva
RD 24 abr 2026