RT Journal Article
T1 Reprogramming tumor-associated macrophages using STING or TLR agonists: a promising strategy to enhance immunotherapy in hormonedependent cancers
A1 Sacristán Santos, Víctor
A1 Pensado López, Alba
A1 García Campelo, Rosario
A1 Antolín Novoa, Silvia
A1 Señarís Rodríguez, Rosa María
A1 Torres Andón, Fernando
K1 Immunotherapy
K1 Macrophage
K1 Nanoparticle
K1 Solid tumor
K1 Toll-like receptor - TLR
AB Hormone-dependent cancers, like breast and prostate cancers, represent a unique challenge in oncology due to their complex interplay between hormone signaling, immune evasion, and therapeutic resistance. While endocrine therapies effectively target hormone signaling to initially control disease, resistance mechanisms frequently emerge, leading to cancer progression and limited survival. These solid tumors further complicate treatment by establishing an immunosuppressive tumor microenvironment (TME), presenting variable numbers of immune cells depending on cancer type and stage, which hinders the efficacy of immune checkpoint inhibitors. In this TME, tumor-associated macrophages (TAMs) are the major cellular source of immunosuppression, supporting tumor growth. The ability of TAMs to hamper the effectiveness of endocrine therapy is becoming increasingly recognized. Reprogramming TAMs within solid tumors can restore their natural ability to fight cancer and also enhance antitumoral efficacy. In this line of research, Al-Janabi et al have recently developed lipid nanoparticles decorated with antibodies that bind to the folate receptor-beta overexpressed in perivascular TAMs and loaded with a STING agonist (cGAMP) for the reprogramming of these TAMs. In preclinical murine models of prostate cancer, this therapeutic approach demonstrated significant synergistic activity with androgen deprivation therapy. This work provides an excellent example of TAM reprogramming combined with endocrine therapy for the treatment of hormone-dependent cancers.
PB BMJ Journals
SN 2051-1426
YR 2025
FD 2025-05-15
LK https://hdl.handle.net/10347/43341
UL https://hdl.handle.net/10347/43341
LA eng
NO Sacristan Santos V, Pensado-López A, García-Campelo R, Antolin Novoa S, Señaris Rodriguez R, Andón FT. Reprogramming tumor-associated macrophages using STING or TLR agonists: a promising strategy to enhance immunotherapy in hormone-dependent cancers. Journal for ImmunoTherapy of Cancer. 2025;13:e010950. https://doi.org/10.1136/jitc-2024-010950
NO Instituto de Salud Carlos III (ISCIII)
NO Xunta de Galicia
NO Worldwide Cancer Research
DS Minerva
RD 24 abr 2026