RT Journal Article
T1 Oxidation-labile linkers for controlled drug delivery
A1 Carneiro Viqueira, Aitor
A1 Santana Penín, María Lourdes
A1 Matos, Maria João Correia Pinto Carvalho de
K1 Bioconjugates: Linkers
K1 Oxidative stress
K1 Drug development
AB The continuous symbiosis throughout chemical biology and drug discovery has led to the design of innovative bifunctional molecules for targeted and controlled drug delivery. Among the different tools, protein-drug and peptide-drug conjugates are trend approaches to achieve targeted delivery, selectivity and efficacy. To meet the main goals of these bioconjugates, the selection of the appropriate payloads and linkers is crucial, as they must provide in vivo stability, while they may also help to achieve the therapeutic target and action. In neurodegenerative diseases or some cancer types, where oxidative stress plays an important role, linkers sensitive to oxidative conditions may be able to release the drug once the conjugate achieves the target. Considering specially this specific application, this mini-review covers the most relevant publications on oxidation-labile linkers
PB Elsevier
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30625
UL http://hdl.handle.net/10347/30625
LA eng
NO Bioorg. Med. Chem. Lett. 87 (2023) 129264
NO M.J.M. thanks Ministerio de Ciencia e Innovación (PID2020-116076RJ-I00/AEI/10.13039/501100011033) for the financial support. A.C. thanks FCT for the PhD grant (2021.05149.BD)
DS Minerva
RD 9 jun 2026