RT Journal Article
T1 Obestatin controls skeletal muscle fiber-type determination
A1 Santos Zas, Icía
A1 Cid Díaz, Tania
A1 González Sánchez, Jessica
A1 Gurriarán Rodríguez, Uxía
A1 Seoane Mosteiro, Carlos
A1 Porteiro Couto, Begoña
A1 Nogueiras Pozo, Rubén
A1 Casabiell Pintos, Jesús Antonio
A1 Relova Quinteiro, José Luis
A1 Gallego Gómez, Rosalía
A1 Mouly, Vincent
A1 Pazos Randulfe, Yolanda
A1 Pérez Camiña, Jesús
K1 Obestatin/GPR39
K1 Skeletal muscle
AB Obestatin/GPR39 signaling stimulates skeletal muscle growth and repair by inducing both G-protein-dependent and -independent mechanisms linking the activated GPR39 receptor with distinct sets of accessory and effector proteins. In this work, we describe a new level of activity where obestatin signaling plays a role in the formation, contractile properties and metabolic profile of skeletal muscle through determination of oxidative fiber type. Our data indicate that obestatin regulates Mef2 activity and PGC-1α expression. Both mechanisms result in a shift in muscle metabolism and function. The increase in Mef2 and PGC-1α signaling activates oxidative capacity, whereas Akt/mTOR signaling positively regulates myofiber growth. Taken together, these data indicate that the obestatin signaling acts on muscle fiber-type program in skeletal muscle
PB Springer nature
SN 2045-2322
YR 2017
FD 2017-05-18
LK https://hdl.handle.net/10347/45195
UL https://hdl.handle.net/10347/45195
LA eng
NO Santos-Zas, I., Cid-Díaz, T., González-Sánchez, J. et al. Obestatin controls skeletal muscle fiber-type determination. Sci Rep 7, 2137 (2017). https://doi.org/10.1038/s41598-017-02337-4
NO This work was supported by grants from Instituto de Salud Carlos III (ISCIII; PI15/01537) and FEDER Funds (MINECO, Spain), and PRIS Program (SERGAS, Spain). The work of JP Camiña and Y Pazos are funded by the SERGAS through a research-staff stabilization contract. IDIS funds T Cid through a pre-doctorate research scholarship. Xunta de Galicia funds J Gonzalez through a pre-doctorate research scholarship. Marta Picado Barreiro from IDIS (Santiago de Compostela, Spain) is greatly acknowledged for assistance with microscope experiments, as well as the platform for immortalization of human cells from the Myology Institute (Paris, France)
DS Minerva
RD 23 may 2026