RT Journal Article
T1 Coronary Artery Disease in Very Young Women: Risk Factors and Prognostic Insights from Extended Follow-Up
A1 Pintos-Rodríguez, Samuel
A1 Jiménez Díaz, Víctor Alfonso
A1 Veiga, César
A1 Martínez García, Carlos
A1 Caamaño Isorna, Francisco
A1 Íñiguez Romo, Andrés
A1 Juan-Salvadores, Pablo
K1 Castelli index
K1 Coronary artery disease
K1 Depression
K1 Percutaneous coronary intervention
K1 Secondary prevention
K1 Young women
AB Coronary artery disease (CAD) is usually associated with the elderly, but an increase in its incidence has been recently reported among young people, including very young women. The aim of this study is to assess the associations between different clinical variables and the risk of early CAD and occurrence of major adverse cardiovascular events (MACEs) during follow-up. Our cohort consists of women ≤40 years referred for coronary angiography due to suspicion of CAD; a nested case–control study was conducted among these patients. In total, 19,321 coronary angiographies were performed between 2006 and 2015, of which 2.6% were in patients ≤40 years old; 52 women were finally included. Family history of CAD was strongly associated with the early onset of the disease [OR 5.94, 95%CI (1.13–31.15); p = 0.035] in young women. The incidence of MACE was also associated with depression [HR 8.20 95%CI (1.03–65.17); p = 0.047] and Castelli Index [HR 11.49, 95%CI (1.40–94.51); p = 0.023]. Primary prevention focused on genetic analysis for high-risk women with a family history of CAD and secondary prevention, targeting a better cholesterol management and mental health assistance must be considered.
PB MDPI
SN 2308-3425
YR 2025
FD 2025
LK https://hdl.handle.net/10347/45813
UL https://hdl.handle.net/10347/45813
LA eng
NO Pintos-Rodríguez, S., Jiménez Díaz, V. A., Veiga, C., Martínez García, C., Caamaño Isorna, F., Íñiguez Romo, A., & Juan-Salvadores, P. (2025). Coronary Artery Disease in Very Young Women: Risk Factors and Prognostic Insights from Extended Follow-Up †. Journal of Cardiovascular Development and Disease, 12(2). https://doi.org/10.3390/JCDD12020034
NO This research has been partially supported by Axencia Galega de Innovación-GAIN through programme code IN607B-2024/07.
DS Minerva
RD 24 abr 2026