RT Journal Article
T1 Bioorthogonal Synthetic Chemistry Enabled by Visible-Light Photocatalysis
A1 Tomás Gamasa, María
A1 Mato Gómez, Mauro
A1 Fernández González, Xulián
A1 D'Avino, Cinzia
A1 Mascareñas Cid, José Luis
K1 Bioorthogonal chemistry
K1 Photocatalysis
K1 Photoredox
K1 In vivo synthesis
K1 Biomolecule modification
AB The field of bioorthogonal chemistry has revolutionized our ability to interrogate and manipulate biological systems at the molecular level. However, the range of chemical reactions that can operate efficiently in biological environments without interfering with the native cellular machinery, remains limited. In this context, the rapidly growing area of photocatalysis offers a promising avenue for developing new type of bioorthogonal tools. The inherent mildness, tunability, chemoselectivity, and external controllability of photocatalytic transformations make them particularly well-suited for applications in biological and living systems. This minireview summarizes recent advances in bioorthogonal photocatalytic technologies, with a particular focus on their potential to enable the selective generation of designed products within biologically relevant or living settings.
PB Wiley
SN 1433-7851
YR 2024
FD 2024-08-12
LK https://hdl.handle.net/10347/38144
UL https://hdl.handle.net/10347/38144
LA eng
NO Mato, M., Fernández-González, X., D'Avino, C., Tomás-Gamasa, M., Mascareñas, J. L. (2024). Bioorthogonal Synthetic Chemistry Enabled by Visible-Light Photocatalysis. “Angew. Chem. Int. Ed.”, 63(47). https://doi.org/10.1002/anie.202413506
NO This work has received financial support from Spanishgrants (Grant RYC2020-029150-I funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in yourfuture”, Grants PID2019-108624RB-I00 and PID2022-137318OB-I00 funded by MCIN/AEI/10.13039/501100011033, Grant IHRC22-00009 funded by MCIN/ISCIII and by the “European Union NextGeneration EU/PRTR”, and ORFEO-CINQA network RED2022-134287-T), the Xunta de Galicia (Grant ED431C 2021/25 and GrantED431G 2023/03: Centro de investigación do Sistemauniversitario de Galicia accreditation 2023–2027) and theEuropean Union (European Regional Development Fund-ERDF corresponding to the multiannual financial frame-work 2014–2020). We thank MINECO for PhD fellowshipto XFG (PRE2020-095031).
DS Minerva
RD 28 abr 2026