RT Journal Article T1 Chemical safety and risk assessment of bio-based and/or biodegradable polymers for food contact: A review A1 Lestido Cardama, Antía A1 Barbosa Pereira, Letricia A1 Sendón García, Raquel A1 Bustos, Juana A1 Paseiro Losada, Perfecto A1 Rodríguez Bernaldo de Quirós, Ana Isabel K1 Bio-based K1 Biodegradable K1 Packaging materials K1 Food safety K1 Analytical techniques K1 Migration K1 Risk assessment AB Bio-based and/or biodegradable polymers are being developed and applied as a sustainable and innovative alternative to conventional petroleum-based materials for food packaging applications.From the chemical standpoint, bio-based and/or biodegradable polymers present a complex chemical composition that includes additives, monomers, and other starting substances, but also, oligomers, impurities, degradation products, etc. All these compounds may migrate into the food and can be a hazard to the consumers’ health. Thus, identifying potential migrants is crucial to assess the safety of these materials. The analytical methods applied to investigate migrants in bio-based and/or biodegradable polymers are reviewed and commented on. Mostly, gas chromatography or liquid chromatography coupled to mass spectrometry and specifically high-resolution mass spectrometry are the techniques of choice. In addition, a summary of recently published migration studies of chemicals from bio-based and/or biodegradable polymers into food simulants and food is provided. Moreover, current approaches to risk assessment of packaging materials are presented and illustrated with examples. Therefore, this review aims to highlight the chemical safety issues raised by biopolymers for food contact applications, that are often overlooked. PB Elsevier YR 2025 FD 2025 LK https://hdl.handle.net/10347/43015 UL https://hdl.handle.net/10347/43015 LA eng NO Food Research International Volume 202, February 2025, 115737 NO This study was funded by the Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación and by Fondo Europeo de Desarrollo Regional (FEDER). Ref. No. PID2021-124729NB- I00 “MIGRABIOQUANT” (MCIN/AEI/ https://doi.org/10.13039/501100011033/FEDER, UE). DS Minerva RD 30 abr 2026