RT Journal Article
T1 Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics
A1 Méndez Ardoy, Alejandro
A1 Bayón Fernández, Alfonso
A1 Yu, Ziyi
A1 Abell, Chris
A1 Granja Guillán, Juan Ramón
A1 Montenegro García, Javier
K1 Cyclic peptides
K1 Self-assembly
K1 Nanotubes
K1 Supramolecular chemistry
K1 Microfluidics
K1 Dropets
AB The recent advances in the supramolecular polymerization of synthetic building blocks in aqueous conditions has given rise to new artificial and biocompatible functional materials. However, despite the importance of spatially resolved self‐assembly for natural and artificial molecular machines, the spatial control of supramolecular polymerization with synthetic monomers has not been experimentally established yet. Here we describe a microfluidic‐regulated tandem process of supramolecular polymerization and droplet encapsulation to control the position of self‐assembled microfibrillar bundles of cyclic peptide nanotubes in water droplets. This method allowed the precise preferential localization of the fibres either at the interface or into the core of the droplets. UV absorbance, circular dichroism and fluorescence microscopy indicated that the microfluidic control of the stimuli (changes in pH or ionic strength) can be employed to adjust the packing degree and the spatial position of microfibrillar bundles of cyclic peptide nanotubes. Additionally, this spatially organized supramolecular polymerization of peptide nanotubes was applied in the assembly of highly ordered two‐dimensional droplet networks
PB Wiley
YR 2020
FD 2020
LK http://hdl.handle.net/10347/20680
UL http://hdl.handle.net/10347/20680
LA eng
NO Mendez-Ardoy, A., Bayón-Fernández, A., Yu, Z., Abell, C., Granja, J..R. and Montenegro, J. (2020), Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics. Angew. Chem.. doi:10.1002/ange.202000103
NO This work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [SAF2017-89890-R, CTQ2016-78423-R], the Xunta de Galicia (ED431G/09, ED431C 2017/25 and 2016-AD031) and the ERDF. A. M.-A. received a MCIF from the EC (GLYCONANOPEP-750248). J. M. holds a Ramón y Cajal (RYC-2013-13784), an ERC-Stg (DYNAP-677786) and a Young Investigator Grant from the HFSP (RGY0066/2017). J. R. G. thanks to the mobility program (PRX17/00147)
DS Minerva
RD 4 may 2026