RT Journal Article
T1 Mismatch negativity (MMN) amplitude as a biomarker of sensory memory deficit in amnestic mild cognitive impairment
A1 Lindín Novo, Mónica
A1 Correa Jaraba, Kenia Shaily
A1 Zurrón Ocio, Montserrat
A1 Díaz Fernández, Fernando
K1 Alzheimer's disease
K1 Amnestic mild cognitive impairment
K1 Biomarkers
K1 Mistmatch negativity
K1 Sensory memory
K1 Event-related potentials
AB It has been suggested that changes in some event-related potential (ERP) parameters associated with controlled processing of stimuli could be used as biomarkers of amnestic mild cognitive impairment (aMCI). However, data regarding the suitability of ERP components associated with automatic and involuntary processing of stimuli for this purpose are not conclusive. In the present study, we studied the Mismatch Negativity (MMN) component, a correlate of the automatic detection of changes in the acoustic environment, in healthy adults and adults with aMCI (age range: 50-87 years). An auditory-visual attention-distraction task, in two evaluations separated by an interval of between 18 and 24 months, was used. In both evaluations, the MMN amplitude was significantly smaller in the aMCI adults than in the control adults. In the first evaluation, such differences were observed for the subgroup of adults between 50 and 64 years of age, but not for the subgroup of 65 years and over. In the aMCI adults, the MMN amplitude was significantly smaller in the second evaluation than in the first evaluation, but no significant changes were observed in the control adult group. The MMN amplitude was found to be a sensitive and specific biomarker of aMCI, in both the first and second evaluation
PB Frontiers
YR 2013
FD 2013-11-20
LK http://hdl.handle.net/10347/15500
UL http://hdl.handle.net/10347/15500
LA eng
NO Lindín, M., Correa, K., Zurrón, M., & Díaz, F. (2013). Mismatch negativity (MMN) amplitude as a biomarker of sensory memory deficit in amnestic mild cognitive impairment. "Frontiers in Aging Neuroscience", 5 doi:10.3389/fnagi.2013.00079
NO The authors thank the participants and their relatives. They also thank S. Galdo, A. Buján, J. Cespón, D. Pinal, M. Ramos, C. Libisch, and S. Cid for help in the sample selection, electroencephalographic recordings and ERP processing
NO This work was financially supported by funds from the Spanish Ministerio Economía y Competitividad (PSI2010-22224-C03-03), and from the Galician Government: Consellería de Industria e Innovación/Economía e Industria (PGIDIT07PXIB211018PR, 10 PXIB 211070 PR), and Consellería de Educación e Ordenación Universitaria (Axudas para a Consolidación e Estruturación de unidades de investigación competitivas do sistema universitario de Galicia. Modalidade: Grupos con potencial de crecimento. Ref: CN 2012/033)
DS Minerva
RD 24 abr 2026