RT Journal Article
T1 Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents
A1 Metelkina, Olga
A1 Lodge, Rhys
A1 Rudakovskaya, Polina
A1 gerasimov, Vasiliy M.
A1 Herreros Lucas, Carlos
A1 Grebennikov, Ivan
A1 Shchetinin, Igor
A1 Savchenko, Alexander
A1 Pavlovskaya, Galina
A1 Rance, Graham
A1 Giménez López, María del Carmen
A1 Khlobystov, Andrei N.
A1 Majouga, Alexander
K1 Nanoparticle
K1 Nanofibre
K1 Carbon Nanotube
K1 Magnetism
K1 Magnetic resonance imaging
AB Magnetic nanomaterials show significant promise as contrast agents for magnetic resonanceimaging (MRI). We have developed a new highly efficient one-step procedure for thesynthesis of magnetically-functionalised hollow carbon nanofibres, where (i) the carbonnanofibres act as both a template and a support for the nucleation and growth of magnetitenanoparticles and (ii) the structural (size, dispersity and morphology) and functional(magnetisation and coercivity) properties of the magnetic nanoparticles formed onnanofibres are strictly controlled by the mass ratio of the magnetite precursor to thenanofibres and the solvent employed during synthesis. We have shown that our magnetitenanofibrematerials are effectively solubilised in water resulting in a stable suspension thathas been employed as a “negative” MRI contrast agent with an excellent transverse relaxivity(r2) of (268 ± 13) mM/s, surpassing current commercial materials and state-of-the-artmagnetic nanoscale platforms in performance for MRI contrast at high magnetic fields. The2preparation and evaluation of this unique hybrid nanomaterial represents a critical steptowards the realisation of a highly efficient “smart” MRI theranostic agent – a material thatallows for the combined diagnosis (with MRI), treatment (with magnetic targeting) andfollow-up of a disease (with MRI) – currently in high demand for various clinical applications,including stratified nanomedicine.
PB The Royal Society of Chemistry
YR 2017
FD 2017-01-30
LK http://hdl.handle.net/10347/32353
UL http://hdl.handle.net/10347/32353
LA eng
NO Metelkina, O.N., Lodge, R.W., Rudakovskaya, P.G., Gerasimov, V.M., Herreros Lucas, C., Grebennikov, I.S., Shchetinin, I.V., Savchenko, A.G., Pavlovskaya, G.E., Rance, G.A., Gimenez-Lopez, M.C., Khlobystov, A.N., Majouga, A.G. (2017). Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents. "Journal of Materials Chemistry C", vol. 5, n. 8, 2167-2174
NO The authors are grateful to the Nanoscale & Microscale Research Centre (nmRC) for access to TEM and Raman facilities. This work was supported by a Russian Federation Ministry of Science and Education Grant No. 14.607.21.0132 (RFMEFI60715X0132) and the University of Nottingham Advanced Molecular Materials for Healthcare Research Priority Area.
DS Minerva
RD 4 may 2026