RT Journal Article
T1 Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK
A1 Martínez de Morentín, Pablo B.
A1 González García, Ismael
A1 Martins, Luís
A1 Lage Fernández, Ricardo
A1 Fernández Mallo, Diana
A1 Martínez Sánchez, Noelia
A1 Ruíz Pino, Francisco
A1 Liu, Ji
A1 Morgan, Donald A.
A1 Pinilla, Leonor
A1 Gallego Gómez, María Rosalía
A1 Saha, Asish K.
A1 Kalsbeek, Andries
A1 Fliers, Eric
A1 Bisschop, Peter
A1 Diéguez González, Carlos
A1 Nogueiras Pozo, Rubén
A1 Rahmouni, Kamal
A1 Tena Sempere, Manuel
A1 López Pérez, Miguel A.
AB Estrogens play a major role in the modulation of energy balance through central and peripheral actions. Here, we demonstrate that central action of estradiol (E2) inhibits AMP-activated protein kinase (AMPK) through estrogen receptor alpha (ERα) selectively in the ventromedial nucleus of the hypothalamus (VMH), leading to activation of thermogenesis in brown adipose tissue (BAT) through the sympathetic nervous system (SNS) in a feeding-independent manner. Genetic activation of AMPK in the VMH prevented E2-induced increase in BAT-mediated thermogenesis and weight loss. Notably, fluctuations in E2 levels during estrous cycle also modulate this integrated physiological network. Together, these findings demonstrate that E2 regulation of the VMH AMPK-SNS-BAT axis is an important determinant of energy balance and suggest that dysregulation in this axis may account for the common changes in energy homeostasis and obesity linked to dysfunction of the female gonadal axis
PB Elsevier
SN 1550-4131
YR 2014
FD 2014
LK http://hdl.handle.net/10347/32449
UL http://hdl.handle.net/10347/32449
LA eng
NO Cell Metabolism. Volume 20, Issue 1, 1 July 2014, Pages 41-53
NO The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 281854, the ObERStress European Research Council Project (M.L.), and 245009, the Neurofast project (R.N., C.D., and M.L.); Xunta de Galicia (R.N.: EM 2012/039 and 2012-CP069; M.L.: 2012-CP070); Junta de Andalucía (M.T.S.: P08-CVI-03788); Instituto de Salud Carlos III (ISCIII) (M.L.: PI12/01814); MINECO cofunded by the FEDER Program of EU (M.T.S.: BFU2011-25021; R.N.: RyC-2008-02219 and BFU2012-35255; C.D.: BFU2011-29102); KNAW (P.H.B.: CEP-09CDP030); ZonMw (A.K.: TOP91207036); and NIH (K.R.: HL084207). L.M. is a recipient of a fellowship from Fundação para a Ciência e Tecnologia, Portugal (SFRH/BD/65379/2009). I.G.-G. is a recipient of a fellowship from Ministerio de Educación, Cultura y Deporte (FPU12/01827). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII
DS Minerva
RD 28 abr 2026