RT Journal Article T1 Characterization of polyphenolic compounds extracted from different varieties of almond hulls (prunus dulcis L.) A1 Kahlaoui, Maher A1 Borotto Dalla Vecchia, Stefania A1 Giovine, Francesco A1 Ben Haj Kbaier, Hayet A1 Bouzouita, Nabiha A1 Barbosa Pereira, Letricia A1 Zeppa, Giuseppe K1 Almond hull K1 Prunus dulcis L K1 Ultrasound-assisted extraction K1 Response surface methodology K1 Radical scavenging activity K1 Polyphenols AB Ultrasound-assisted extraction (UAE) was applied as a pretreatment technique to improve the recovery of polyphenols from the almond hulls of four Tunisian and three Italian almond varieties, followed by the characterization with HPLC-DAD. The operating parameters (solid/liquid ratio, extraction time, and ethanol concentrations) were optimized using a Response Surface Methodology. A polynomial equation was calculated to describe the relationship between the operating parameters and dependent variables as total polyphenolic content (TPC) and antioxidant activity (RSA). A desirability function approach was used to determine the optimum conditions for operating parameters: a solid:solvent ratio of 2 g/100 mL, an extraction time of 13 min, and an ethanol concentration of 51.2%. Among the almond varieties, Pizzuta and Fakhfekh showed the highest polyphenol content and antioxidant activity. HPLC-DAD analysis of almond hull extracts confirmed that chlorogenic acid, catechin, and protocatechuic acid were the most important polyphenols in almond hull. The results highlighted that UAE could be an effective technique for the recovery of phenolic compounds from almond hull, thereby making this byproduct a promising source of compounds with potential applications in food and healthcare sectors PB MDPI YR 2019 FD 2019 LK http://hdl.handle.net/10347/21072 UL http://hdl.handle.net/10347/21072 LA eng NO Kahlaoui, M.; Borotto Dalla Vecchia, S.; Giovine, F.; Ben Haj Kbaier, H.; Bouzouita, N.; Barbosa Pereira, L.; Zeppa, G. Characterization of Polyphenolic Compounds Extracted from Different Varieties of Almond Hulls (Prunus dulcis L.). Antioxidants 2019, 8, 647 NO This study was financially supported by the Ministry of Higher Education and Scientific Research and Tunisia Carthage University, under DP-2017-BALT “Academic and Educational Mission of Tunisia”, as well as by the University of Torino, Research Direction and Doctorates Section, under mobility support from the Cotutelle Agreement Grant (No. D.D.n.2622) DS Minerva RD 24 abr 2026