RT Journal Article
T1 Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury
A1 Sousa, Nidia de
A1 Robledo Sánchez, Diego
A1 González Llera, Laura
A1 Pinho, Andreia G.
A1 Santos, Diogo J.
A1 Monteiro, Susana
A1 Campos, Jonas
A1 Cibrão, Jorge R.
A1 Silva, Nuno A.
A1 Sánchez Piñón, Laura
A1 Salgado, António J.
A1 Barreiro Iglesias, Antón
K1 Baclofen
K1 Spinal cord injury
K1 RNA-seq
K1 Traumatic nervous system injury
K1 Neuroprotection
K1 Regeneration
AB Spinal cord injury (SCI) leads to severe functional deficits. Currently, there are no available pharmacological treatments to promote neurological recovery in SCI patients. Recent work from our group has shown that a baclofen treatment can promote functional recovery after a compression SCI in mice [1]. Here, we provide transcriptomic (RNA-seq) data from adult mouse spinal cords collected 7 days after a compression SCI and baclofen (vs vehicle) administration. The Illumina NovaSeq 6000 platform was used to generate the raw transcriptomic data. In addition, we also present bioinformatic analyses including differential gene expression analysis, enrichment analyses for various functional annotations (gene ontology, KEGG and BioCarta pathways or InterPro domains) and transcription factor targets. The raw RNA-seq data has been uploaded to the NCBI Sequence Read Archive (SRA) database (Bioproject ID PRJNA886048). The data generated from the bioinformatic analyses is contained within the article
PB Elsevier
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29881
UL http://hdl.handle.net/10347/29881
LA eng
NO Data in Brief  46 (2023) 108809
NO This work was supported by the Wings for Life Spinal Cord Research Foundation (grant reference WFL-ES-03/19), the Portuguese Foundation for Science and Technology (FCT) EXPL/MED-FAR/1529/2021 to N. de Sousa and through the Scientific Employment Stimulus to N. Silva and S. Monteiro (CEECIND/04794/2017 and CEECIND/01902/2017) and Grant PID2020-115121GB-I00 funded by MCIN/AEI/10.13039/501100011033 to A. Barreiro-Iglesias
DS Minerva
RD 24 abr 2026