RT Journal Article
T1 Vancomycin-loaded chitosan aerogel particles for chronic wound applications
A1 García González, Carlos A.
A1 López-Iglesias, Clara
A1 Barros, Joana
A1 Ardao Palacios, Inés
A1 Monteiro, Fernando J.
A1 Álvarez Lorenzo, Carmen
A1 Gómez Amoza, José Luis
K1 Chitosan
K1 Aerogel
K1 Chronic wounds
K1 Antimicrobial
AB Chronic wounds are a prevailing cause of decreased quality of life, being microbial burden a factor hindering the normal wound healing process. Aerogels are nanostructured materials with large surface area (>250 m2/g) and high porosity (>96%). In this work, vancomycin-loaded chitosan aerogel beads were tested as a potential formulation to treat and prevent infections at the wound site. Processing of chitosan in the form of aerogels endowed this polysaccharide with enhanced water sorption capacity and air permeability. The morphological and textural properties of the particles were studied by image and N2 adsorption-desorption analysis and scanning electron microscopy. Vancomycin content and release profiles from aerogel carriers showed a fast drug release that permitted to efficiently achieve local therapeutic levels. Cell studies with fibroblasts and antimicrobial tests against S. aureus showed that the particles vancomycin-loaded aerogels were cytocompatible and effective in preventing high bacterial loads at the wound site.
PB Elsevier
SN 0144-8617
YR 2018
FD 2018
LK http://hdl.handle.net/10347/32496
UL http://hdl.handle.net/10347/32496
LA eng
NO Lopez-Iglesias C, Barros J, Ardao I, Monteiro FJ, Alvarez- Lorenzo C, Gomez-Amoza JL, Garcıa-Gonzalez CA, Vancomycin-loaded chitosan aerogel particles for chronic wound applications, Carbohydrate Polymers (2018), https://doi.org/10.1016/j.carbpol.2018.10.012
NO This work was supported by Xunta de Galicia [ED431F 2016/010] & [ED431C 2016/008]MINECO [SAF2017-83118-R], Agencia Estatal de Investigación (AEI) of Spain and FEDER.C.A. García-González acknowledges to MINECO for a Ramón y Cajal Fellowship [RYC2014-15239].
DS Minerva
RD 29 abr 2026