RT Journal Article
T1 Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
A1 Rial Pensado, Eva
A1 Rivas Limeres, Verónica
A1 Grijota Martínez, Carmen
A1 Rodríguez Díaz, Amanda
A1 Capelli, Vallentina
A1 Barca Mayo, Olga
A1 Nogueiras Pozo, Rubén
A1 Mittag, Jens
A1 Diéguez González, Carlos
A1 López Pérez, Miguel A.
K1 Thyroid hormones
K1 Temperature
K1 Thermogenesis
K1 Brown Adippose Tissue
K1 Hypothalamus
K1 AMPK
AB Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic after TH administration, mice gain weight; so, these differences in species need to be analyzed in detail and specially whether temperature could be a factor. Here, we aimed to investigate the effect of environmental temperature on those actions. Rats were subcutaneously treated with L-thyroxine (T4) or stereotaxically within the ventromedial nucleus of the hypothalamus (VMH) with triiodothyronine (T3) and housed at 23°C, 4°C or 30°C; energy balance, BAT thermogenesis and AMP-activated protein kinase (AMPK) in the VMH were analyzed. Our data showed that the effect of both systemic T4 of central T3 on energy balance and BAT thermogenesis was dependent upon environmental temperature. This evidence is of interest in the design of experimental settings highlighting the species-specific metabolic actions of THs, and in understanding its physiological role in the adaptation to temperature.
PB Frontiers Media
SN 1664-042X
YR 2022
FD 2022-11-18
LK https://hdl.handle.net/10347/38692
UL https://hdl.handle.net/10347/38692
LA eng
NO Rial Pensado, E., Rivas-Limeres, V., Grijota-Martínez, C., Rodríguez-Díaz, A., Capelli, C., Barca-Mayo, O., Nogueiras, R., Mittag, J., Diéguez, C., López, M. (2022). Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis. "Frontiers in Physiology", vol. 13, 1017381.
NO This research was funded by: Ministerio de Ciencia y Universidades co-funded by the FEDER Program of EU (CD: BFU 2017-87721; RN: RTI 2018-099413-B-I00 and RED 2018- 102379-T; ML: RTI 2018-101840-B-I00, PID2021-128145NB- I00 and PDC2022-133958-I00). “la Caixa” Foundation (ID100010434), under the agreement LCF/PR/HR19/52160022 (ML); European Research Council (RN: ERC Synergy Grant- 2019-WATCH- 810331). Conflict of intere
DS Minerva
RD 24 abr 2026