RT Dissertation/Thesis
T1 Liquid biopsy: circulating tumor cells utility in precision medicine
A1 Pereira Veiga, Tais
K1 Circulating tumor cell
K1 Liquid biopsy
K1 Breast cancer
K1 Xenograft
AB Metastatic disease is the leading cause of cancer associated deaths. Circulating tumour cells(CTCs) are responsible for tumoral dissemination, as they are able to be released from the primarytumour and establish distal metastatic foci. The objective of this doctoral thesis is to increase theknowledge of CTCs, through the use of liquid biopsy. To this aim, with the use of blood samplesfrom metastatic cancer patients we identified key biomarkers for cancer progression. In thiscontext, different experimental approaches were considered: the validation of new technologies forthe study of CTCs, the isolation and molecular analysis of CTCs and the establishment of in vivomodels.
YR 2019
FD 2019
LK http://hdl.handle.net/10347/19470
UL http://hdl.handle.net/10347/19470
LA eng
DS Minerva
RD 23 abr 2026