RT Journal Article
T1 Evaluation of Celiac Disease by Minimally Invasive Biomarkers in a Spanish Pediatric Population
A1 Cabo del Riego, Julia María
A1 Núñez Iglesias, María Jesús
A1 García-Plata González, Carmen
A1 Paz Carreira, José
A1 Álvarez Fernández, Tamara
A1 Dorado Díaz, Ana
A1 Villar Mallo, Noa
A1 Penedo Pita, Manuel
A1 Novío Mallón, Silvia
A1 Máiz Suárez, Lola
A1 Freire-Garabal Núñez, Manuel
K1 Non-invasive biomarkers
K1 Celiac disease
K1 ESPGHAN
K1 Diagnosis
K1 Antibodies
K1 Pediatric age
AB Background: The diagnosis of celiac disease (CD) has been substantially improved with the availability of highly sensitive CD-specific IgA-TG2, Ig-GDP, and IgA-EMA. The European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) published (2012) andupdated (2020) diagnostic criteria for CD in order to simplify CD diagnosis and to avoid biopsies in selected patients. Methods: A prospective study including 5641 pediatric patients (0–16 years old) from January 2012 to January 2019 was performed. CD diagnosis was made according to the ESPGHAN algorithm. The objective of this study was to evaluate the utility of biomarkers and the relationship between TGA-IgA and EMA titers. Results: CD diagnoses were confirmed in 113 patients, 110 were IgA-TG2-positive and 3 (2.7%) had IgA deficiency. The diagnosis was made by serologic tests in 95 (84.1%) patients. Only 18 (15.9%) patients underwent intestinal biopsy. We obtained 100% concordance between IgA-EMA and positive results for IgA-TG2 ≥ 10 ULN with IgAEMA antibody titer ≥1:80. Conclusions: This study provides evidence of a positive correlation between IgA-TG2 antibody serum levels and IgA-EMA. The diagnosis could be guaranteed with strict application of IgA-TG2 values ≥10 ULN (confirmed by subsequent testing) plus the serological response to the gluten-free diet (GFD).
PB MDPI
SN 1660-4601
YR 2022
FD 2022-04-20
LK https://hdl.handle.net/10347/43327
UL https://hdl.handle.net/10347/43327
LA eng
NO Cabo del Riego, J.M.; Núñez Iglesias, M.J.; García-Plata González, C.; Paz Carreira, J.; Álvarez Fernández, T.; Dorado Díaz, A.; Villar Mallo, N.; Penedo Pita, M.; Novío Mallón, S.; Máiz Suárez, L.; et al. Evaluation of Celiac Disease by Minimally Invasive Biomarkers in a Spanish Pediatric Population. Int. J. Environ. Res. Public Health 2022, 19, 5020. https://doi.org/10.3390/ ijerph19095020
DS Minerva
RD 1 may 2026