RT Journal Article
T1 Circulating miR-451a Expression May Predict Recurrence in Atrial Fibrillation Patients after Catheter Pulmonary Vein Ablation
A1 Lage Fernández, Ricardo
A1 Cebro Márquez, María
A1 Vilar Sánchez, Marta
A1 González Melchor, Laila
A1 García Seara, Javier
A1 Martínez Sande, José Luis
A1 Fernández López, Xesús Alberte
A1 Aragón Herrera, Alana
A1 Martínez Monzonís, María Amparo
A1 González Juanatey, José Ramón
A1 Rodríguez Mañero, Moisés
A1 Moscoso Galán, Isabel
K1 Atrial fibrillation
K1 microRNAs
K1 Biomarker
K1 Recurrence
K1 miR-451a
K1 Scar percentage
AB Atrial fibrillation is the most prevalent tachyarrhythmia in clinical practice, with very high cardiovascular morbidity and mortality with a high-cost impact in health systems. Currently, it is one of the main causes of stroke and subsequent heart failure and sudden death. miRNAs mediate in several processes involved in cardiovascular disease, including fibrosis and electrical and structural remodeling. Several studies suggest a key role of miRNAs in the course and maintenance of atrial fibrillation. In our study, we aimed to identify the differential expression of circulating miRNAs and their predictive value as biomarkers of recurrence in atrial fibrillation patients undergoing catheter pulmonary vein ablation. To this effect, 42 atrial fibrillation patients were recruited for catheter ablation. We measured the expression of 84 miRNAs in non-recurrent and recurrent groups (45.2%), both in plasma from peripheral and left atrium blood. Expression analysis showed that miRNA-451a is downregulated in recurrent patients. Receiver operating characteristic curve analysis showed that miR-451a in left atrium plasma could predict atrial fibrillation recurrence after pulmonary vein isolation. In addition, atrial fibrillation recurrence is positively associated with the increment of scar percentage. Our data suggest that miRNA-451a expression plays an important role in AF recurrence by controlling fibrosis and progression
PB MDPI
YR 2023
FD 2023
LK http://hdl.handle.net/10347/32194
UL http://hdl.handle.net/10347/32194
LA eng
NO Lage, R.; Cebro-Márquez, M.; Vilar-Sánchez, M.E.; González-Melchor, L.; García-Seara, J.; Martínez-Sande, J.L.; Fernández-López, X.A.; Aragón-Herrera, A.; Martínez-Monzonís, M.A.; González-Juanatey, J.R.; et al. Circulating miR-451a Expression May Predict Recurrence in Atrial Fibrillation Patients after Catheter Pulmonary Vein Ablation. Cells 2023, 12, 638. https://doi.org/10.3390/cells12040638
NO This research was funded by Xunta de Galicia: Programa de Consolidación de Unidades de Investigación Competitivas do SUG (GRC 2019/02), the Centro Singular de Investigación de Galicia acreditación 2019–2022 (ED431G 2019/02), the European Union European Regional Development Fund (ERDF), and National Institute of Health “Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III (ISCIII)” Madrid, Spain (PI18/00821 and CIBERCV CB16/11/00226)
DS Minerva
RD 24 abr 2026