RT Journal Article
T1 Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort
A1 Rial, Manuel J.
A1 Salgado Castro, Francisco Javier
A1 Pozo, Victoria del
AB Introduction: The MEGA (MEchanism underlying the Genesis and evolution of Asthma) project is a multicenter cohort study carried out in eight Spanish hospitals, gathering clinical, physiological, and molecular data from patients with asthma and multimorbidities in order to gain insight into the different physiopathological mechanisms involved in this disorder.Material and Methods: We report the baseline clinical and physiological characteristics and biomarker measures of adult participants in the project with the aim of better understanding the natural history and underlying mechanisms of asthma as well as the associated multimorbidities across different levels of severity. We carried out a detailed clinical examination, pulmonary function testing, measurement of fractional exhaled nitric oxide (FeNO), blood counts, induced sputum, skin prick tests, chest computed tomography scan, asthma questionnaires, and multimorbidity assessment in 512 asthmatic patients.Results: When compared to patients with milder disease, severe asthmatic patients showed greater presence of symptoms, more exacerbations, lower asthma control, increased airflow obstruction, and higher frequency of chronic rhinosinusitis with nasal polyps, severe rhinitis, anxiety and depression, gastroesophageal reflux, and bronchiectasis.Conclusion: The MEGA project succeeded in recruiting a high number of asthma patients, especially those with severe disease, who showed lower control and higher frequency of multimorbidities.
PB John Wiley and Sons Ltd (on behalf of European Academy of Allergy and Clinical Immunology)
SN 2045-7022
YR 2021
FD 2021-03-27
LK https://hdl.handle.net/10347/39225
UL https://hdl.handle.net/10347/39225
LA eng
NO Rial MJ, Álvarez‐Puebla MJ, Arismendi E, et al. Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort. Clin Transl Allergy. 2021;11:e12001. https://doi.org/10.1002/ clt2.12001
NO Sanofi [02/055]
NO the Merck Health Foundation
NO CIBER de Enfermedades Respiratorias (CIBERES), a Carlos III Institute of Health initiative
NO FEDER funds
DS Minerva
RD 23 abr 2026