RT Journal Article
T1 Electrophysiological Correlates of Amnestic Mild Cognitive Impairment in a Simon Task
A1 Cespón, Jesús
A1 Galdo Álvarez, Santiago
A1 Díaz Fernández, Fernando
K1 Aged
K1 Aged, 80 and over
K1 Amnesia
K1 Behavior
K1 Electroencephalography
K1 Electrophysiological phenomena
K1 Evoked potentials
K1 Middle aged
K1 Mild cognitive impairment
K1 Neuropsychological tests
K1 Reaction time
K1 Adult
K1 Attention
K1 Brain electrophysiology
K1 Contingent negative variation
K1 Controlled study
K1 Correlation analysis
K1 Depth perception
K1 Electrooculography
K1 Event related potential
K1 Female
K1 Human
K1 Male
K1 Motor performance
K1 Sensitivity and specificity
K1 Stimulus response
K1 Task performance
K1 Very elderly
K1 Complication
K1 Electrophysiology
K1 Evoked response
K1 Neuropsychological test
K1 Pathophysiology
K1 Physiology
AB Amnestic mild cognitive impairment (aMCI) represents a prodromal stage of Alzheimer`s disease (AD), especially when additional cognitive domains are affected (Petersen et al., 2009). Thus, single-domain amnestic MCI (sdaMCI) and multipledomain-amnestic MCI (mdaMCI) biomarkers are important for enabling early interventions to help slow down progression of the disease. Recording event-related potentials (ERPs) is a non-invasive and inexpensive measure of brain activity associated with cognitive processes, and it is of interest from a clinical point of view. The ERP technique may also be useful for obtaining early sdaMCI and mdaMCI biomarkers because ERPs are sensitive to impairment in processes that are not manifested at behavioral or clinical levels. In the present study, EEG activity was recorded in 25 healthy participants and 30 amnestic MCI patients (17 sdaMCI and 13 mdaMCI) while they performed a Simon task. The ERPs associated with visuospatial (N2 posterior-contralateral – N2pc -) and motor (lateralized readiness potential – LRP –) processes were examined. The N2pc amplitude was smaller in participants with mdaMCI than in healthy participants, which indicated a decline in the correlates of allocation of attentional resources to the target stimulus. In addition, N2pc amplitude proved to be a moderately good biomarker of mdaMCI subtype (0.77 sensitivity, 0.76 specificity). However, the LRP amplitude was smaller in the two MCI groups (sdaMCI and mdaMCI) than in healthy participants, revealing a reduction in the motor resources available to execute the response in sdaMCI and mdaMCI patients. Furthermore, the LRP amplitude proved to be a valid biomarker (0.80 sensitivity, 0.92 specificity) of both amnestic MCI subtypes
PB PLoS
YR 2013
FD 2013-12-05
LK http://hdl.handle.net/10347/15499
UL http://hdl.handle.net/10347/15499
LA eng
NO Cespón J, Galdo-Álvarez S, Díaz F (2013) Electrophysiological Correlates of Amnestic Mild Cognitive Impairment in a Simon Task. "PLoS ONE" 8(12): e81506. https://doi.org/10.1371/journal.pone.0081506
NO This study was financially supported by funds from the Spanish Government: Ministerios de Educación (Beca FPU AP2007-04362) and Economía y Competitividad (PSI2010-22224-C03-03), and from the Galician Government: Consellería de Economía e Industria (10 PXIB 211070 PR), and Consellería de Educación e Ordenación Universitaria (Axudas para a Consolidación e Estruturación de unidades de investigación competitivas do sistema universitario de Galicia. Modalidade: Grupos con potencial de crecemento. Ref: CN 2012/033). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
DS Minerva
RD 24 abr 2026