RT Journal Article
T1 Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs
A1 Cadete, Ana
A1 Olivera, Ana
A1 Besev, Magnus
A1 Dhal, Pradeep
A1 Gonçalves, Lídia
A1 Almeida, António J.
A1 Bastiat, Guillaume
A1 Benoit, Jean-Pierre
A1 Fuente, María de la
A1 García Fuentes, Marcos
A1 Alonso Fernández, María José
A1 Torres López, Dolores
K1 Cell delivery
K1 Chemical modification
K1 Drug delivery
K1 Nanoparticles
AB Preparation of sophisticated delivery systems for nanomedicine applications generally involve multi-step procedures using organic solvents. In this study, we have developed a simple self-assembling process to prepare docetaxel-loaded hyaluronic acid (HA) nanocapsules by using a self-emulsification process without the need of organic solvents, heat or high shear forces. These nanocapsules, which comprise an oily core and a shell consisting of an assembly of surfactants and hydrophobically modified HA, have a mean size of 130 nm, a zeta potential of −20 mV, and exhibit high docetaxel encapsulation efficiency. The nanocapsules exhibited an adequate stability in plasma. Furthermore, in vitro studies performed using A549 lung cancer cells, showed effective intracellular delivery of docetaxel. On the other hand, blank nanocapsules showed very low cytotoxicity. Overall, these results highlight the potential of self-emulsifying HA nanocapsules for intracellular drug delivery.
PB Nature Publishing Group
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21340
UL http://hdl.handle.net/10347/21340
LA eng
NO Cadete, A., Olivera, A., Besev, M. et al. Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs. Sci Rep 9, 11565 (2019). https://doi.org/10.1038/s41598-019-47995-8
NO The authors acknowledge financial support from Xunta de Galicia (Competitive Reference Groups-FEDER Funds GRC2013-043). A. Cadete acknowledges her doctoral fellowship from the European Commission (EACEA) under the Nanofar program, Erasmus Mundus Joint Doctorate (EMJD). A. Olivera acknowledges her doctoral fellowship from the Spanish Ministry of Science, Innovation and Universities (grant number BES-2015-071236)
DS Minerva
RD 22 abr 2026