RT Journal Article
T1 Palladium-Catalyzed Enantioselective C–H Arylations and Alkenylations of 2-Aminobiaryls with Atmospheric Air as the Sole Oxidant
A1 Goicoechea Crespo, Laura
A1 Losada Castro, Pablo
A1 Mascareñas Cid, José Luis
A1 Gulías Costa, Moisés
AB Optically active 2-aminobiaryls are valuable chiral frameworks with broad applications in catalysis, synthetic chemistry, and materials science. Here, we present a simple and practical methodology for their asymmetric synthesis via enantioselective palladium catalyzed C−H arylations or alkenylations of racemic precursors. The methodology utilizes a kinetic resolution strategy, producing two highly valuable enantioenriched axially chiral molecules: the C−C coupling product and the unreacted starting material. Notably, we have established reaction conditions that enable the in situ regeneration of the active Pd(II) catalyst using atmospheric air as the sole oxidant. Finally, we showcase the synthetic utility of this approach by preparing several derivatives relevant to the field of asymmetric catalysis.
PB Wiley
SN 1433-7851
YR 2025
FD 2025-02-24
LK https://hdl.handle.net/10347/42448
UL https://hdl.handle.net/10347/42448
LA eng
NO L. Goicoechea, P. Losada, J. L. Mascareñas, M. Gulías (2025). Palladium-Catalyzed Enantioselective C–H Arylations and Alkenylations of 2-Aminobiaryls with Atmospheric Air as the Sole Oxidant. Angew. Chem. Int. Ed. 2025, 64, e202425512. https://doi.org/10.1002/anie.202425512
NO This work has received financial support from Spanish grants PID2022-137318OB−I00 and PID2022-136785NB−I00 funded by MCIN/AEI/10.13039/501100011033, Grant IHRC22-00009 funded by MCIN/ISCIII and the “European Union Next Generation EU/PRTR”, and “ERDF A way of making Europe”. We also thank the ORFEO−CINQA network (RED2022-134287-T), the Consellería de Cultura, Educación e Ordenación Universitaria (Grant ED431 C 2021/25 and Centro Singular de Investigación de Galicia accreditation 2023–2027, ED431G 2023/03) and the European Union (European Regional Development Fund-ERDF corresponding to the multiannual financial framework 2014–2020). We thank the Spanish Government for the FPU fellowship to L.G. and Xunta de Galicia for the fellowship to P. L.
DS Minerva
RD 24 abr 2026