RT Journal Article
T1 Interferon beta promotes survival in primary astrocytes through phosphatidylinositol 3-kinase.
A1 Barca Mayo, Olga
A1 Ferré, Susana
A1 Seoane, Marcos
A1 Prieto, Jose María
A1 Lema, Manuela
A1 Señarís Rodríguez, Rosa María
A1 Arce Vázquez, Víctor Manuel
K1 Interferon beta
K1 Astrocytes
K1 Multiple Sclerosis
K1 Apoptosis
AB Although interferon-β (IFN-β) has been demonstrated to be effective in the treatment of multiple sclerosis (MS) patients, the mechanism(s) underlying its beneficial effects has not been uncovered yet. Until now, most of the effort in the study of the relevant mechanisms of IFN-β has dealt with its ability to modulate the immune response. Only recently, it has been proposed that the beneficial effects of IFN-β in MS patients could depend on its ability to modulate astrocyte function. In the present work, we have found that IFN-β treatment promotes the survival of astrocytes through stimulation of the phosphatidylinositol 3-kinase (PI-3K)/Akt pathway. We propose that the beneficial effects of IFN-β in MS therapy may depend, at least in part, on its capacity to protect astrocytes against the apoptotic cell death that occurs in the early steps of the pathogenesis of MS.
PB Elsevier
SN 0165-5728
YR 2003
FD 2003-06-01
LK https://hdl.handle.net/10347/38856
UL https://hdl.handle.net/10347/38856
LA eng
NO Barca Mayo, O., Ferré, S., Seoane, M., Prieto, J. M., Lema, M., Señarís, R. M., Arce, V. M. (2003). Interferon beta promotes survival in primary astrocytes through phosphatidylinositol 3-kinase. Journal of Neuroimmunology, 139(1-2), 155-159.
NO Fondo de Investigaciones Sanitarias (FIS 99/1188 and FIS 01/1007)
DS Minerva
RD 23 abr 2026