RT Dissertation/Thesis
T1 Radioresistance in lung cancer: a molecular approach
A1 Gómez Casal, Roberto
K1 lung cancer
K1 HSP90
K1 radioresistance
K1 DNA repair
K1 radiation
K1 cancer stem cells
K1 epithelialmesenchymal transition
AB Lung cancer represents one-quarter of the deaths caused by cancer.Despite the advances in treatments, chemo and radiotherapy remain the foundation of treatment for this disease,and the survival rate is still at 10%, mainly due to the recurrences after treatment. Tumors that re-emerge after aradiation treatment are usually radioresistant and challenging to treat. This research shows that lung cancer cellsthat have survived treatment with radiation therapy show characteristics of cancer stem cells and epithelial tomesenchymal transition. Moreover, radioresistant non-small cell lung cancer exhibited alterations of critical prosurvivalsignaling pathways, higher expression and activation of DNA repair genes, and altered expression ofcytokines and receptors.
YR 2021
FD 2021
LK http://hdl.handle.net/10347/27048
UL http://hdl.handle.net/10347/27048
LA eng
DS Minerva
RD 22 abr 2026