RT Dissertation/Thesis
T1 Obestatin/gpr39: an autocrine-paracrine system involved in differentiation, glucose metabolism and regeneration
A1 Gurriarán Rodríguez, Uxía
A2 Facultade de Medicina e Odontoloxía. Departamento de Medicina. Laboratorio de Endocrinoloxía Celular, 
K1 células mesenquimais (MSCs)
K1 glucose metabolism and regeneration
K1 Obestatin/gpr39
AB White adipose tissue and skeletal muscle are the largest organs in the bodyand both are composed of distinct cell types with a common origin, themesenchymal steam cells. The adipose tissue is composed by the adipocytewhile myocyte are the defining cell of skeletal muscle. Both adipocyte andmyocyte secrete a range of bioactive molecules that are involved in localautocrine/paracrine interactions as well as in an endocrine cross-talk with othertissues. Based on it, the main aim of the present work was to explore and tovalidate the role of the obestatin/GPR39 system in the differentiation programthat determines adipogenesis and myogenesis. This aim was divided in thefollowing points:1. To determine the role of the obestatina/GPR39 system, asautocrine/paracrine signal, in the adipogenic program and on adipocytemetabolism.3. To establish the role of the obestatin/GPR39 system as autocrine/paracrinesignal in the myogenesis and on muscle metabolism.5. To validate the use of obestatin as a potential therapeutic peptide for skeletalmuscle regeneration.6. To determine the action of obestatin in the activation and differentiation ofsatellite stem cells from skeletal muscle.
YR 2014
FD 2014-03-19
LK http://hdl.handle.net/10347/10009
UL http://hdl.handle.net/10347/10009
LA eng
DS Minerva
RD 24 abr 2026