RT Journal Article
T1 Postoperative serum levels of sCD26 for surveillance in colorectal cancer patients
A1 Chiara, Loretta De
A1 Rodríguez Piñeiro, Ana M.
A1 Cordero Santamaría, Óscar Javier
A1 Vázquez Tuñas, Lidia
A1 Ayude, Daniel
A1 Rodríguez Berrocal, Francisco Javier
A1 Páez de la Cadena, María
K1 Tumor
K1 soluble CD26
K1 Colorectal Cancer
AB One of the main aims of the follow-up after curative resection of colorectal cancer is the early detection and treatment oftumor recurrence. We previously demonstrated decreased preoperative soluble CD26 (sCD26) levels in serum fromcolorectal cancer patients. We extended now the study to investigate if sCD26 levels in postoperative serum serve as markerof recurrence of the disease during surveillance. Soluble sCD26 was measured in pre- and postoperative serum samples of43 patients with primary colorectal cancer. Carcinoembryonic antigen, carbohydrate antigen 19.9 and 72.4 levels were alsomeasured during surveillance. The average follow-up period was 41.8620.8 months. sCD26 levels during follow-up showedwell-defined patterns in patients without disease (n = 28), and in patients with tumor persistence (n = 2), local recurrence(n = 3) or distant metastasis (n = 10). Disease-free patients showed stable levels between 460–850 ng/mL during follow-up,while high (over 850 ng/mL) and unstable sCD26 levels were found before recurrence was diagnosed. The mean maximum/minimum sCD26 ratios during surveillance were 1.52, 2.12 and 2.63 for patients with no recurrence, local recurrence andmetastasis, respectively (p = 0.005). From the cut-off obtained from a receiver operator characteristics (ROC) curve built withthe maximum/minimum sCD26 ratios and the upper and lower cut-offs of sCD26, we were able to discriminate patientswith and without recurrent disease. We propose that the measurement of serum sCD26 during the follow-up of patientsdiagnosed of colorectal cancer could be valuable for the early detection of local and distant recurrence. A large,randomized, prospective trial should be performed to confirm our findings
PB PLOS
YR 2014
FD 2014
LK http://hdl.handle.net/10347/22633
UL http://hdl.handle.net/10347/22633
LA eng
NO De Chiara L, Rodríguez-Piñeiro AM, Cordero OJ, Vázquez-Tuñas L, Ayude D, Rodríguez-Berrocal FJ, et al. (2014) Postoperative Serum Levels of sCD26 for Surveillance in Colorectal Cancer Patients. PLoS ONE 9(9): e107470. https://doi.org/10.1371/journal.pone.0107470
NO This work was partially supported by Agrupación Estratégica INBIOMED (Investigación en Biomedicina) (2012/273 and CN 2011/024), from DXPCTSUG (Dirección Xeral de Promoción Científica e Tecnolóxica do Sistema Universitario de Galicia) and FEDER (Fondo Europeo de Desarrollo Regional) funding. LD is supported by “Fundación Científica de la Asociación Española contra el Cáncer” (GCB13131592CAST)
DS Minerva
RD 24 abr 2026