RT Journal Article T1 Management of Pathological Dental Attrition in Prader–Willi Syndrome: A Case Report Using the Personalized Radboud Strategy A1 Tayebi Hillali, Hoda A1 Fernández Alonso, Pablo A1 Rivas Mundiña, Berta A1 Outumuro Rial, Mercedes A1 Diniz Freitas, Márcio A1 Fernández Feijoo, Javier K1 Behavioral management K1 Case report K1 Dental wear K1 General anesthesia K1 Prader–Willi syndrome K1 Removable prosthesis AB Prader–Willi syndrome (PWS) is a rare genetic disorder characterized by obesity, hypotonia, intellectual disability, and behavioral disturbances that complicate dental management. Parafunctional habits such as bruxism often lead to severe tooth wear, while cooperation and anesthesia represent additional challenges. A 34-year-old woman with genetically confirmed PWS presented with generalized dental wear, poor oral hygiene, and multiple carious lesions. Preventive and splint therapies were initially proposed but not feasible. Two years later, she returned with pain due to pulp exposure. Because of limited cooperation and comorbidities, dental treatment under general anesthesia was planned in two sessions, including molar extractions and multiple root canal treatments. Complete acrylic dentures with metal reinforcement were fabricated, restoring vertical dimension, improving esthetics, and serving as protective splints. Caregivers were instructed on hygiene, and annual follow-up was established. After six years, bone atrophy and further wear were noted, but the patient continued using relined prostheses without sedation. This case demonstrates that a resolutive, interdisciplinary approach can successfully manage complex dental problems in PWS. General anesthesia minimized the number of interventions while ensuring comprehensive care. Reinforced acrylic dentures provided a functional, aesthetic, and cost-effective solution, despite the progressive nature of dental wear and bone loss. PB Wiley SN 0275-1879 YR 2026 FD 2026 LK https://hdl.handle.net/10347/46843 UL https://hdl.handle.net/10347/46843 LA eng NO Tayebi-Hillali, H., Fernández Alonso, P., Rivas-Mundiña, B., Outumuro Rial, M., Diniz-Freitas, M., & Fernández Feijoo, J. (2026). Management of Pathological Dental Attrition in Prader–Willi Syndrome: A Case Report Using the Personalized Radboud Strategy. Special Care in Dentistry, 46(1). https://doi.org/10.1111/scd.70149 NO The authors declare that no funding or external support was received for the preparation of this case report. DS Minerva RD 6 may 2026