RT Journal Article
T1 New nitrogen compounds coupled to phenolic units with antioxidant and antifungal activities: synthesis and structure–activity relationship
A1 Bettencourt, Ana
A1 Castro Pérez, María de los Ángeles
A1 Silva, João
A1 Fernandes, Francisco
A1 Coutinho, Olga
A1 Sousa, M. João
A1 Proença, M. Fernanda
A1 Areias, Filipe
K1 Imidazoles
K1 Phenolic compounds
K1 Antifungal activity
K1 MIC
K1 Antioxidant capacity
K1 Structure-activity relationship
AB A selection of 1-amino-2-arylidenamine-1,2-(dicyano)ethenes 3 was synthesized and cyclized to 2-aryl-4,5-dicyano-1H-imidazoles 4 upon reflux in ethyl acetate/acetonitrile, in the presence of manganese dioxide. These compounds were tested for their antioxidant capacity by cyclic voltammetry, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and deoxyribose degradation assays. The minimum inhibitory concentration of all compounds was evaluated against two yeast species, Saccharomyces cerevisiae and Candida albicans. Their toxicity was tested in mammal fibroblasts. Among the synthesised compounds, two presented dual antioxidant/antifungal activity without toxic effects in fibroblasts. The new compounds synthesized in this work are potential biochemical tools and/or therapeutic drugs
PB MDPI
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22506
UL http://hdl.handle.net/10347/22506
LA eng
NO Bettencourt, A.; Castro, M.; Silva, J.; Fernandes, F.; Coutinho, O.; Sousa, M.J.; Proença, M.F.; Areias, F. New Nitrogen Compounds Coupled to Phenolic Units with Antioxidant and Antifungal Activities: Synthesis and Structure–Activity Relationship. Molecules 2018, 23, 2530
NO This research was funded by the Portuguese Fundação para a Ciência e Tecnologia (PPCDT/QUI/59356).Filipe Areias gratefully acknowledges a post-PhD grant from the Portuguese FCT (SFRH/BPD/26106)
DS Minerva
RD 27 abr 2026