RT Journal Article
T1 Are Differences in Inflammatory Markers between Patients with and without Hypertension-Mediated Organ Damage Influenced by Circadian Blood Pressure Abnormalities?
A1 Vázquez Agra, Néstor
A1 Marques Afonso, Ana Teresa
A1 Cruces Sande, Antón
A1 Novo Veleiro, Ignacio
A1 López Paz, José Enrique
A1 Pose Reino, Antonio
A1 Hermida Ameijeiras, Álvaro
K1 Blood pressure
K1 Arterial hypertension
K1 Inflammatory markers
K1 Hypertension-mediated organ damage
AB We aimed to explore the influence that the circadian blood pressure (BP) profile could exert on the correlation between some inflammatory markers and hypertension-mediated organ damage (HMOD). This was a cross-sectional study that included patients with primary arterial hypertension older than 18 years old. We included some parameters of 24 h ambulatory blood pressure monitoring collection and several inflammatory markers, as follows: platelet count (PTC), erythrocyte sedimentation rate (ESR), ultrasensitive C-reactive-protein, ferritin, fibrinogen, and uric acid. Myocardial hypertrophy, albuminuria, carotid intima-media thicknesses and ankle brachial index were assessed as HMOD presentations. Individuals were divided into two groups: patients with and without HMOD. We included 522 patients (47% women, mean age of 54 years). Multivariate logistic regression analysis showed that male patients older than 50 years old with uric acid levels above 7 mg/dL, ESR higher than 20 mm/h, fibrinogen greater than 320 mg/dL and PTC lower than 275 × 103/µL were associated with HMOD (p < 0.05). The circadian BP profile (dipper versus non-dipper pattern) did reach neither statistical significance nor influence the odds ratio of those inflammatory markers for HMOD. We found that differences in some inflammatory markers between patients with and without HMOD were not explained by a different circadian BP profile
PB MDPI
YR 2022
FD 2022-02-25
LK https://hdl.handle.net/10347/38873
UL https://hdl.handle.net/10347/38873
LA eng
NO Vazquez-Agra, N.; Marques-Afonso, A.-T.; Cruces-Sande, A.; Novo-Veleiro, I.; Lopez-Paz, J.-E.; Pose-Reino, A.; Hermida-Ameijeiras, A. Are Differences in Inflammatory Markers between Patients with and without Hypertension-Mediated Organ Damage Influenced by Circadian Blood Pressure Abnormalities? J. Clin. Med. 2022, 11, 1252. https:// doi.org/10.3390/jcm11051252
DS Minerva
RD 1 may 2026