RT Dissertation/Thesis
T1 Liquid Biopsies for Precision Medicine in Colorectal and Head and Neck Cancers: Saliva and Blood Biomarkers
A1 Rapado González, Óscar
K1 Liquid Biopsies
K1 Precision Medicine
K1 Precision Oncology
K1 Biomarkers
K1 Head and Neck cancer
AB Liquid biopsies have emerged as an innovative tool in precision oncologyrepresenting a valuable complement to traditional tumor biopsy for detecting, characterizing, and monitoring cancer.Liquid biopsies comprise the non-invasive analysis of tumor-derived material including circulating tumor cells, cellfreenucleic acids, extracellular vesicles, and tumor-derived platelets in different body fluids, such as blood andsaliva. Scientific evidence has highlighted the potential value of saliva analyses in the oncology field. Advances insaliva-omics demonstrated the feasibility to detect different tumor biomarkers in saliva providing a non-invasivestrategy to assess cancer diagnosis, progression, and therapeutic efficacy. The objective of this doctoral thesis wasto identify biomarkers with clinical utility in liquid biopsies of saliva and plasma from colorectal and head and neckcancer patients. In colorectal cancer, we performed a pioneer characterization of salivary microRNAs and identifiedpotential diagnostic biomarkers. In head and neck cancer, different molecular approaches were carried out toimprove its non-invasive characterization, including characterization of salivary cell-free DNA, assessment ofsomatic mutations in plasma and saliva, and profiling of salivary DNA methylation.
YR 2022
FD 2022
LK http://hdl.handle.net/10347/27681
UL http://hdl.handle.net/10347/27681
LA eng
DS Minerva
RD 25 abr 2026