RT Journal Article
T1 Cell senescence is an antiviral defense mechanism
A1 Baz-Martínez, Maite
A1 Silva Álvarez, Sabela da
A1 Rodríguez, Estefanía
A1 Guerra Varela, Jorge
A1 El Motiam, Ahmed
A1 Vidal Figueroa, Anxo
A1 García-Caballero Parada, Tomás
A1 González Barcia, Miguel
A1 Sánchez Piñón, Laura
A1 Muñoz Fontela, Cesar
A1 Collado Rodríguez, Manuel
A1 Rivas Vázquez, Carmen
AB Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activators of cell senescence. Apart from a characteristic stable cell cycle arrest, this response also involves a proinflammatory phenotype known as senescence-associated secretory phenotype (SASP). This, together with the widely known interference with senescence pathways by some oncoviruses, had led to the hypothesis that senescence may also be part of the host cell response to fight virus. Here, we evaluate this hypothesis using vesicular stomatitis virus (VSV) as a model. Our results show that VSV replication is significantly impaired in both primary and tumor senescent cells in comparison with non-senescent cells, and independently of the stimulus used to trigger senescence. Importantly, we also demonstrate a protective effect of senescence against VSV in vivo. Finally, our results identify the SASP as the major contributor to the antiviral defense exerted by cell senescence in vitro, and points to a role activating and recruiting the immune system to clear out the infection. Thus, our study indicates that cell senescence has also a role as a natural antiviral defense mechanism.
PB Nature Publishing Group
YR 2016
FD 2016
LK http://hdl.handle.net/10347/22869
UL http://hdl.handle.net/10347/22869
LA eng
NO Baz-Martínez, M., Da Silva-Álvarez, S., Rodríguez, E. et al. Cell senescence is an antiviral defense mechanism. Sci Rep 6, 37007 (2016). https://doi.org/10.1038/srep37007
NO This work was supported by Grant BFU2014- 58530-P from the Ministry of Economy and Competitiveness of Spain and EU-FEDER. MC is a Miguel Servet investigator supported by an ISCIII and EU-FEDER grant (PI14/00554). AEM is a recipient of a FPI predoctoral fellowship from the Ministry of Economy and Competitiveness of Spain
DS Minerva
RD 29 abr 2026