RT Journal Article
T1 Coeliac Disease Case–Control Study: Has the Time Come to Explore beyond Patients at Risk?
A1 Castillejo, Gemma
A1 Ochoa-Sangrador, Carlos
A1 Perez-Solis, David
A1 Cileruelo, Maria Luz
A1 Donat, Ester
A1 Garcia-Burriel, Jose ignacio
A1 Sanchez-Valverde, Felix
A1 Garcia-Calatayud, Salvador
A1 Eizaguirre, Francisco Javier
A1 Martinez-Ojinaga, Eva
A1 Barros, Patricia
A1 Leis Trabazo, María Rosaura
A1 Salazar, Jose Carlos
A1 Barrio, Josefa
A1 Peña-Quintana, Luis
A1 Luque, Veronica
A1 Polanco, Isabel
A1 Riber, Carmen
A1 Roman, Enriqueta
K1 coeliac disease
K1 general practice
K1 pediatric gastroenterology
K1 screening
AB The worldwide prevalence of asymptomatic coeliac disease (CD) is increasing, which is in part due to the routine screening of children with risk factors. Both symptomatic and asymptomatic patients with CD are at risk of long-term complications. The objective of this study was to compare the clinical characteristics of asymptomatic and symptomatic children at the time of CD diagnosis. A case-control study was conducted using data from a cohort of 4838 CD patients recruited from 73 centers across Spain between 2011 and 2017. A total of 468 asymptomatic patients (cases) were selected and matched by age and sex with 468 symptomatic patients (controls). Clinical data, including any reported symptoms, as well as serologic, genetic, and histopathologic data were collected. No significant differences were found between the two groups in most clinical variables, nor in the degree of intestinal lesion. However, the asymptomatic patients were taller (height z-score -0.12 (1.06) vs. -0.45 (1.19), p < 0.001) and were less likely to have anti transglutaminase IgA antibodies ≥ 10 times the upper normal limit (66.2% vs. 758.4%, p = 0.002). Among the 37.1% of asymptomatic patients who were not screened for CD due to the absence of risk factors, only 34% were truly asymptomatic, while the remaining 66% reported non-specific CD-related symptoms. Therefore, expanding CD screening to any child who undergoes a blood test could reduce the burden of care for some children, as many of those considered asymptomatic reported non-specific CD-related symptoms.
PB MDPI
YR 2023
FD 2023-03-03
LK https://hdl.handle.net/10347/45339
UL https://hdl.handle.net/10347/45339
LA eng
NO Castillejo, G., Ochoa-Sangrador, C., Pérez-Solís, D., Cilleruelo, M. L., Donat, E., García-Burriel, J. I., Sánchez-Valverde, F., Garcia-Calatayud, S., Eizaguirre, F. J., Martinez-Ojinaga, E., Barros, P., Leis, R., Salazar, J. C., Barrio, J., Peña-Quintana, L., Luque, V., Polanco, I., Ribes, C., Roman, E., & Coeliac Disease Working Group of the Spanish Paediatric Gastroenterology, Hepatology and Nutrition Society (SEGHNP) (2023). Coeliac Disease Case-Control Study: Has the Time Come to Explore beyond Patients at Risk?. Nutrients, 15(5), 1267. https://doi.org/10.3390/nu15051267
NO This research received no external funding.
DS Minerva
RD 3 may 2026