RT Journal Article
T1 In vitro models for neuropathic pain phenotypic screening in brain therapeutics
A1 Martínez Rodríguez, Antón Leandro
A1 Brea Floriani, José Manuel
A1 López, D.
A1 Cosme Boullosa, Neila
A1 Barro Fernández, Mateo
A1 Monroy, X.
A1 Burgueño, J.
A1 Merlos, M.
A1 Loza García, María Isabel
K1 Phenotypic screening
K1 Immortalized cell lines
K1 In vitro models
K1 Neuropathic pain
K1 In vitro pharmacology
K1 Early drug discovery
AB The discovery of brain therapeutics faces a significant challenge due to the low translatability of preclinical results into clinical success. To address this gap, several efforts have been made to obtain more translatable neuronal models for phenotypic screening. These models allow the selection of active compounds without predetermined knowledge of drug targets. In this review, we present an overview of various existing models within the field, examining their strengths and limitations, particularly in the context of neuropathic pain research. We illustrate the usefulness of these models through a comparative review in three crucial areas: i) the development of novel phenotypic screening strategies specifically for neuropathic pain, ii) the validation of the models for both primary and secondary screening assays, and iii) the use of the models in target deconvolution processes
PB Elsevier
SN 1043-6618
YR 2024
FD 2024
LK http://hdl.handle.net/10347/33869
UL http://hdl.handle.net/10347/33869
LA eng
NO Pharmacological Research, Volume 202, 2024, 107111
NO The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The research for this work was supported by the Agencia Estatal de Investigación (PID2020-119428RB-I00) and Xunta de Galicia (ED431C 2022/20) and European Regional Development Fund (ERDF). NC was in receipt of a predoctoral grant (ED481A 2021) from Xunta de Galicia and MB was in receipt of a predoctoral grant (ED481A-2020) from Xunta de Galicia
DS Minerva
RD 27 abr 2026