RT Journal Article
T1 Palladium-Catalyzed [5 + 2] Rollover Annulation of 1-Benzylpyrazoles with Alkynes: A Direct Entry to Tricyclic 2-Benzazepines
A1 Suárez Lustres, Alejandro
A1 Martínez Yáñez, Nuria
A1 Velasco Rubio, Álvaro
A1 Varela Carrete, Jesús Ángel
A1 Saá Rodríguez, Carlos
K1 Annulations
K1 2-Benzazepines
K1 Cyclization
K1 Palladium catalyst
AB The first Pd-catalyzed [5 + 2] rollover annulation of 1-benzylpyrazoles with alkynes to assemble 10H-benzo[e]pyrazolo[1,5-a]azepines (tricyclic 2-benzazepines) has been developed. The rollover annulation implies a twofold C–H activation of aryl and heteroaryl Csp2–H bonds (C–H/C–H) of 1-benzylpyrazoles (five-atom partners) and alkynes to give the [5 + 2] annulated compounds.
PB American Chemical Society
SN 1523-7060
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30335
UL http://hdl.handle.net/10347/30335
LA eng
NO Suárez-Lustres, A., Martínez-Yáñez, N., Velasco-Rubio, A., Varela, J. A., Saá, C. (2023). Palladium-Catalyzed [5 + 2] Rollover Annulation of 1-Benzylpyrazoles with Alkynes: A Direct Entry to Tricyclic 2-Benzazepines. Org. Lett., 25, 5, 794-799
NO We acknowledge financial support from MICINN (Project PID2020-118048GB-I00 and ORFEO−CINQA NetworkRED2018-102387-T), the Xunta de Galicia (Project ED431C 2022/27 and Centro Singular de Investigación deGalicia Accreditation 2019−2022, ED431G 2019/03), and the European Union (European Regional Development Fund). A.S.-L. thanks MICINN for a predoctoral contract.
DS Minerva
RD 28 abr 2026