RT Journal Article
T1 Fine-tuning oligodendrocyte development by microRNAs
A1 Barca Mayo, Olga
A1 Lu, Q. Richard
K1 miRNAs
K1 Oligodendrocyte
K1 Myelination
K1 Neural cell fate
K1 Feed-back regulation
AB Myelination of axons by oligodendrocytes in the central nervous system is essential for normal neuronal functions. The failure of remyelination due to injury or pathological insults results in devastating demyelinating diseases. Oligodendrocytes originate in restricted regions of the embryonic ventral neural tube. After migration to populate all areas of the brain and spinal cord, oligodendrocyte precursors undergo a temporally well-defined series of molecular and structural changes, ultimately culminating in the cessation of proliferation, and the elaboration of a highly complex myelin sheath. The emergence of microRNAs (miRNAs) as potent regulators of gene expression at the posttranscriptional level has broad implications in all facets of cell biology. Recent studies have demonstrated a critical role of miRNAs in oligodendrocyte development, including cell proliferation, differentiation, and myelin formation. In this review, we will highlight and discuss the recent understanding of functional links of miRNAs to regulatory networks for central myelination, as well as perspectives on the role of miRNAs in demyelinating diseases.
PB Frontiers Media
YR 2012
FD 2012-02-06
LK https://hdl.handle.net/10347/38625
UL https://hdl.handle.net/10347/38625
LA eng
NO Front. Neurosci., 06 February 2012 Sec. Neurogenesis Volume 6 - 2012 | https://doi.org/10.3389/fnins.2012.00013
DS Minerva
RD 27 abr 2026