RT Journal Article
T1 Does empirically derived classification of individuals with subjective cognitive complaints predict dementia?
A1 Picón Prado, Eduardo
A1 Juncos Rabadán, Onésimo
A1 Lojo Seoane, Cristina
A1 Campos Magdaleno, María
A1 Mallo López, Sabela Carme
A1 Nieto Vieites, Ana
A1 Pereiro Rozas, Arturo X.
A1 Facal Mayo, David
K1 Cognitive aging
K1 Mild cognitive impairment
K1 Subjective cognitive complaints
K1 Dementia
K1 Cluster analysis
K1 Compostela aging study
K1 Screening and diagnosis
AB Background: Early identification of mild cognitive impairment (MCI) in people reportingsubjective cognitive complaints (SCC) and the study of progression of cognitive decline are importantissues in dementia research. This paper examines whether empirically derived procedures predictprogression from MCI to dementia. (2) Methods: At baseline, 192 participants with SCC werediagnosed according to clinical criteria as cognitively unimpaired (70), single-domain amnestic MCI(65), multiple-domain amnestic MCI (33) and multiple-domain non-amnestic MCI (24). A two-stagehierarchical cluster analysis was performed for empirical classification. Categorical regression analysiswas then used to assess the predictive value of the clusters obtained. Participants were re-assessedafter 36 months. (3) Results: Participants were grouped into four empirically derived clusters: Cluster1, similar to multiple-domain amnestic MCI; Cluster 2, characterized by subjective cognitive decline(SCD) but with low scores in language and working memory; Cluster 3, with specific deterioration inepisodic memory, similar to single-domain amnestic MCI; and Cluster 4, with SCD but with scoresabove the mean in all domains. The majority of participants who progressed to dementia wereincluded in Cluster 1. (4) Conclusions: Cluster analysis differentiated between MCI and SCD in asample of people with SCC and empirical criteria were more closely associated with progression todementia than standard criteria.
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/20955
UL http://hdl.handle.net/10347/20955
LA eng
NO Picón, E., Juncos-Rabadán, O., Lojo-Seoane, C., Campos Magdaleno, M., Mallo, S. C., Nieto-Vietes, A., Pereiro, A. X., Facal, D. (2019). Does empirically derived classification of individuals with subjective cognitive complaints predict dementia? "Brain Sciences", 9(11), 314
NO This work was financially supported by the Spanish Directorate General of Scientific and Technical Research (Project PSI2014- 55316-C3-1-R) and by the Galician Government (Consellería de Cultura, Educación e Ordenación Universitaria; axudas para a consolidación e Estruturación de unidades de investigación competitivas do Sistema universitario de Galicia; GRC (GI-1807-USC); Ref: ED431-2017/27) through FEDER funds
DS Minerva
RD 30 abr 2026