RT Journal Article
T1 Circulating miR-499a and miR-125b as Potential Predictors of Left Ventricular Ejection Fraction Improvement after Cardiac Resynchronization Therapy
A1 Moscoso Galán, Isabel
A1 Cebro Márquez, María
A1 Martínez Gómez, Álvaro
A1 Abou Jokh Casas, Charigan
A1 Martínez Monzonís, María Amparo
A1 Martínez Sande, José Luis
A1 González Melchor, Laila
A1 García Seara, Javier
A1 Fernández López, Xesús Alberte
A1 Moraña Fernández, Sandra
A1 González Juanatey, José Ramón
A1 Rodríguez Mañero, Moisés
A1 Lage Fernández, Ricardo
K1 Heart failure
K1 Adverse remodelling
K1 Cardiac resynchronization therapy
K1 microRNAs
K1 Cardiac biomarker
K1 Cardiac therapeutic target
AB Cardiac resynchronization therapy represents a therapeutic option for heart failure drug-refractory patients. However, due to the lack of success in 30% of the cases, there is a demand for an in-depth analysis of individual heterogeneity. In this study, we aimed to evaluate the prognostic value of circulating miRNA differences. Responder patients were defined by a composite endpoint of the presence of left ventricular reverse remodelling (a reduction ≥15% in telesystolic volume and an increment ≥10% in left ventricular ejection fraction). Circulating miRNAs signature was analysed at the time of the procedure and at a 6-month follow-up. An expression analysis showed, both at baseline and at follow-up, differences between responders and non-responders. Responders presented lower baseline expressions of miR-499, and at follow-up, downregulation of miR-125b-5p, both associated with a significant improvement in left ventricular ejection fraction. The miRNA profile differences showed a marked sensitivity to distinguish between responders and non-responders. Our data suggest that miRNA differences might contribute to prognostic stratification of patients undergoing cardiac resynchronization therapy and suggest that preimplant cardiac context as well as remodelling response are key to therapeutic success
PB MDPI
YR 2022
FD 2022
LK http://hdl.handle.net/10347/32181
UL http://hdl.handle.net/10347/32181
LA eng
NO Moscoso, I.; Cebro-Márquez, M.; Martínez-Gómez, Á.; Abou-Jokh, C.; Martínez-Monzonís, M.A.; Martínez-Sande, J.L.; González-Melchor, L.; García-Seara, J.; Fernández-López, X.A.; Moraña-Fernández, S.; et al. Circulating miR-499a and miR-125b as Potential Predictors of Left Ventricular Ejection Fraction Improvement after Cardiac Resynchronization Therapy. Cells 2022, 11, 271. https://doi.org/10.3390/cells11020271
NO This work was supported by grants from the Spanish Society of Cardiology (PROYECTOS DE INVESTIGACIÓN SEC-ROVI para la investigación en insuficiencia cardiaca de la Sección de Insuficiencia Cardiaca de la SEC 2017), Xunta de Galicia: Programa de Consolidación de Unidades de Investigación Competitivas do SUG (GPC 2016/022 and GRC 2019/02), the Centro Singular de Investigación de Galicia acreditación 2019–2022 (ED431G 2019/02), the European Union European Regional Development Fund (ERDF), and the Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV).
DS Minerva
RD 26 abr 2026