RT Journal Article
T1 Photo-assembling cyclic peptides for dynamic light-driven peptide Nanotubes
A1 Vilela-Picos, Marcos
A1 Novelli, Federica
A1 Pazó, Antía
A1 Méndez-Ardoy, Alejandro
A1 Marafon, Giulia
A1 Amorín López, Manuel
A1 Moretto, Alessandro
A1 Granja Guillán, Juan Ramón
K1 Nanotubos de péptidos
K1 Fotoensambladores
K1 Isomerización luz-inducida
K1 Polímeros supramoleculares
K1 Microfluidos
AB Cyclic peptides containing a β-unsaturated amino acid are programmed to switch between monomeric form and self-assembled peptide nanotube structures upon light irradiation. The process is triggered by the reversible E-Z isomerization of the unsaturated β-amino acid that forces the peptide to swap from the folded (unassembled) to the flat conformation (assembled). The process is also tuned by the pH media, which provides a double checkpoint control in the molecular assembly of the peptide nanotubes. The light-driven assembly process can be triggered in a confined environment, and the resulting nanotubes allow the inter-vesicle communication, providing droplets with self-fusiogenic properties.
PB Elsevier
SN 2451-9308
YR 2023
FD 2023-11-09
LK https://hdl.handle.net/10347/39030
UL https://hdl.handle.net/10347/39030
LA eng
NO This work was supported by the Spanish Agencia Estatal de Investigación (AEI) and the ERDF (PID2019-111126RB-100) and by the Xunta de Galicia and the ERDF (ED431C 2021/21 and Centro singular de Investigación de Galicia accreditation 2019–2022, ED431G 2019/03). We also thank the ORFEO-CINCA Network and Mineco (RED2018-102331-T). M.V.-P. thanks the Spanish Ministry of Universities for his FPU contract.
DS Minerva
RD 4 may 2026