RT Journal Article
T1 Exosome‑mimetic nanoplatforms for targeted cancer drug delivery
A1 Vázquez Ríos, Abi J.
A1 Molina Crespo, Ángela
A1 López Bouzo, Belén
A1 López López, Rafael
A1 Moreno Bueno, Gema
A1 Fuente Freire, María de la
K1 Exosomes
K1 Exosome-mimetic nanoplatforms
K1 Biomimetics
K1 Drug delivery systems
K1 Gene therapy
K1 Cancer
AB Background: Lack of efective tumor-specifc delivery systems remains an unmet clinical challenge for successfultranslation of innovative therapies, such as, therapeutic oligonucleotides. In the past decade, exosomes have beensuggested to be ideal drug delivery systems with application in a broad range of pathologies including cancer, due totheir organotropic properties. Tumor-derived exosomes, having tumor-homing properties, can efciently reach can‑cer cells and therefore behave as carriers for improved drug delivery to the primary tumor and metastases. However,due to their complex composition, and still undefned biological functions, safety concerns arise hampering theirtranslation to the clinics.Results: We propose here the development of exosome-mimetic nanosystems (EMNs) that simulate naturaltumor-derived exosomes with respect to their structure and functionality, but with a controlled composition, for thetargeted delivery of therapeutic oligonucleotides to lung adenocarcinoma cells (microRNA-145 mimics). Making useof the well-known liposome technology, EMNs can be engineered, loaded with the therapeutic compounds, andtailored with specifc proteins (integrin α6β4) providing them organotropic properties. EMNs show great similarities tonatural exosomes with respect to their physicochemical properties, drug loading capacity, and ability to interact withthe cancer target cells in vitro and in vivo, but are easier to manufacture, can be produced at high yields, and are saferby defnition.Conclusions: We have designed a multifunctional nanoplatform mimicking exosomes, EMNs, and proved theirpotential to reach cancer cells with a similar efcient that tumor-derived exosomes but providing important advan‑tages in terms of production methodology and regulations. Additionally, EMNs are highly versatile systems that canbe tunable for a broader range of applications
PB BMC
SN 1477-3155
YR 2019
FD 2019
LK http://hdl.handle.net/10347/22697
UL http://hdl.handle.net/10347/22697
LA eng
NO Vázquez-Ríos, A.J., Molina-Crespo, Á., Bouzo, B.L., López López, R., Moreno Bueno, G., and Fuente, M. de la. (2019). Exosome-mimetic nanoplatforms for targeted cancer drug delivery. J Nanobiotechnol 17, 85; doi: 10.1186/s12951-019-0517-8
NO This work was in part supported by grants from Instituto de Salud Carlos III (ISCIII) and European Regional Development Fund (FEDER) (CP12/03150, PI15/00828, and CB16/12/00328 from M.F. and PI16/0014, CIBERONC CB16/12/00295 from G.M.B). A.V.R. also acknowledges the fnancial support from the Spanish Ministry of Education, Culture, and Sport (FPU15/06595)
DS Minerva
RD 3 may 2026