RT Journal Article
T1 Resistance of neonatal primary astrocytes against Fas-induced apoptosis depends on silencing of caspase 8
A1 Barca Mayo, Olga
A1 Carneiro, Carmen
A1 Costoya Puente, José Antonio
A1 Señarís Rodríguez, Rosa María
A1 Arce Vázquez, Víctor Manuel
K1 Astrocytes
K1 Fas
K1 Apoptosis
K1 Caspase-8
K1 Epigenetic
AB In the present report, we have found that primary fetal astrocytes express caspase 8 and undergo apoptosis in response to Fas ligation. In contrast, neonatal astrocytes do not express detectable levels of the enzyme and are resistant to Fas killing. Fas-induced apoptosis can be restored in these cells by up-regulation of caspase 8 expression by means of transient transfection with a caspase 8-encoding plasmid. Furthermore, treatment of primary astrocytes with the demethylating agent 5-Aza-dC restores caspase 8 expression and increases the sensibility of neonatal astrocytes to the cytotoxic effect of Fas activation. Altogether, our findings indicate that silencing of caspase 8 gene is a key factor controlling the outcome of neonatal astrocytes upon Fas engagement.
PB Elsevier
SN 0304-3940
YR 2010
FD 2010-05-18
LK https://hdl.handle.net/10347/38853
UL https://hdl.handle.net/10347/38853
LA eng
NO Barca-Mayo, O., Carneiro, C., Costoya, J.A., Señarís, R.M., Arce, V.M. (2010). Resistance of neonatal primary astrocytes against Fas-induced apoptosis depends on silencing of caspase 8. "Neuroscience Letters", vol. 479(3), 206-210.
NO Fondo de Investigaciones Sanitarias (FIS 01/1007) and Xunta de Galicia (PGIDIT05BTF20801PR).
DS Minerva
RD 30 abr 2026